Isolation and Absolute Configuration of SMTP-0, a Simplest Congener of the SMTP Family Nonlysine-analog Plasminogen Modulators

Keiji Hasumi Keiko Hasegawa Yoshikazu Kitano

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Isolation and Absolute Configuration of SMTP-0, a Simplest Congener of the SMTP Family Nonlysine-analog Plasminogen Modulators

机译：SMTP系列非赖氨酸模拟纤溶酶原调节剂的最简单同源者SMTP-0的隔离和绝对配置

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SMTP-0, a new simple congener of the SMTP nonlysine-analog plasminogen modulators, was isolated from a culture of Stachybotrys microspora. Based on the physico-chemical data, SMTP-0 was shown to be an enantiomer of the antimicrobial compound stachybotrin B. The absolute configuration of SMTP-0 was determined by the modified Mosher method. The stereochemistry was further confirmed using an epimer of SMTP-0. Unlike most SMTPs with an amino acid side chain linked to the nitrogen atom of the lactam moiety, SMTP-0, which lacks the N-linked side chain, showed no plasminogen modulator activity.

机译：SMTP-0是SMTP非赖氨酸类似物纤溶酶原调节剂的新的简单同类物，是从Stachybotrys microspora的培养物中分离得到的。根据理化数据，表明SMTP-0是抗菌化合物stachybotrin B的对映体。通过改良的Mosher方法确定SMTP-0的绝对构型。使用SMTP-0差向异构体进一步证实了立体化学。与大多数具有连接到内酰胺部分的氮原子上的氨基酸侧链的SMTP不同，缺少N-连接侧链的SMTP-0没有纤溶酶原调节剂活性。

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来源
《The Journal of Antibiotics: An International Journal》 |2007年第7期|共6页
作者
Keiji Hasumi Keiko Hasegawa Yoshikazu Kitano;
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正文语种 eng
中图分类药学;
关键词
nonlysine-analog plasminogen modulator; absolute configuration; Stachybotrys microspora; microbial triprenyl phenols; modified Mosher method;

机译：非赖氨酸类似物纤溶酶原调节剂;绝对构型;ach小孢子菌;微生物三苯酚;改进的Mosher法;

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1. Isolation and Absolute Configuration of SMTP-0, a Simplest Congener of the SMTP Family Nonlysine-analog Plasminogen Modulators [J] . Keiji Hasumi Keiko Hasegawa Yoshikazu Kitano The Journal of Antibiotics: An International Journal . 2007,第7期

机译：SMTP系列非赖氨酸模拟纤溶酶原调节剂的最简单同源者SMTP-0的隔离和绝对配置
2. Pre-SMTP, a key precursor for the biosynthesis of the SMTP plasminogen modulators [J] . NishimuraY., SuzukiE., HasegawaK., The Journal of Antibiotics: An International Journal . 2012,第9期

机译：SMTP之前，SMTP纤溶酶原调节剂生物合成的关键前体
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Isolation and Absolute Configuration of SMTP-0, a Simplest Congener of the SMTP Family Nonlysine-analog Plasminogen Modulators

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