Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen.

Sasaoka M; Wada Y; Hasumi K

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Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen.

机译：Stachybotrydial选择性增强纤维蛋白结合和Glu-纤溶酶原的激活。

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Stachybotrydial, a triprenyl phenol metabolite from a fungus, has a plasminogen modulator activity selective to Glu-plasminogen. Stachybotrydial enhanced fibrin binding and activation of Glu-plasminogen (2- to 4-fold enhancement at 60~120 muM) but not of Lys-plasminogen. Approximately 1.2~1.6 moles of [(3)H]stachybotrydial bound to Glu-plasminogen to exert such effects. The selective modulation of the Glu-plasminogen function by stachybotrydial may be related to alteration of its conformational status.

机译：Stachybotrydial（一种来自真菌的三苯酚酚代谢物）具有对Glu-纤溶酶原具有选择性的纤溶酶原调节剂活性。水飞蓟宾增强纤维蛋白结合和激活Glu-纤溶酶原（在60〜120μM时增强2到4倍），但不增强Lys-纤溶酶原。大约1.2〜1.6摩尔的[（3）H]水生芽孢菌结合到Glu-纤溶酶原上发挥这种作用。水飞蓟宾对Glu-纤溶酶原功能的选择性调节可能与其构象状态的改变有关。

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《The Journal of Antibiotics: An International Journal》 |2007年第11期|共8页
作者
Sasaoka M; Wada Y; Hasumi K;
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正文语种 eng
中图分类药学;药品;
关键词
Plasminogen; Glutamate; binding; Fibrin measurement; stachybotrydial; 纤维蛋白溶酶原;

机译：Plasminogen;Glutamate;binding;Fibrin measurement;stachybotrydial;纤维蛋白溶酶原;

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专利

1. Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen. [J] . Sasaoka M, Wada Y, Hasumi K The Journal of Antibiotics: An International Journal . 2007,第11期

机译：Stachybotrydial选择性增强纤维蛋白结合和Glu-纤溶酶原的激活。
2. Characterization of a recombinant chimeric plasminogen activator with enhanced fibrin binding [J] . Jianwei Jiao, Meimin Yu, Binggen Ru Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology . 2001,第2期

机译：具有增强的纤维蛋白结合的重组嵌合型纤溶酶原激活剂的表征
3. Enhancement of fibrin binding and activation of plasminogen by staplabin through induction of a conformational change in plasminogen [J] . Endo Akira, Hasumi Keiji, Shinohara Chikara, FEBS Letters . 1997,第1a2期

机译：staplabin通过诱导纤溶酶原的构象变化增强纤维蛋白结合和纤溶酶原的激活
4. MULTIVALENT BINDING AND SELECTIVITY IN CELL TARGETING, MOLECULAR RECOGNITION AND RECEPTOR ACTIVATION [C] . Jure Dobnikar Association in solution IV . 2017

机译：细胞定位，分子识别和受体激活中的多价结合和选择性
5. Activation-enhancement, activation-specific, and auto-activating antibodies binding to the LFA-1 I-domain [D] . Carreno, Roberto 2010

机译：结合LFA-1 I结构域的激活增强，激活特异性和自激活抗体
6. Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA. [O] . O F Wagner, C de Vries, C Hohmann, 1989

机译：与纤维蛋白结合的1型纤溶酶原激活物抑制剂（PAI-1）与组织型纤溶酶原激活物（t-PA）或尿激酶型纤溶酶原激活物（u-PA）之间的相互作用。 t-PA / PAI-1复合物与t-PA的手指和kringle-2结构域介导的纤维蛋白结合。
7. Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen [O] . Masaaki Sasaoka, Yasuko Wada, Keiji Hasumi 2007

机译：Stachybotrydial选择性地增强纤维蛋白结合和胶质纤溶酶的活化
8. Adsorbent with Enhanced Protein Binding Capacity and Selectivity. [R] . Willson, R. C., Balan, S., Potty, A. S. H. 2005

机译：具有增强的蛋白质结合能力和选择性的吸附剂。

Stachybotrydial Selectively Enhances Fibrin Binding and Activation of Glu-plasminogen.

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