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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides SANK 21404.
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Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides SANK 21404.

机译:Colltotoic acid,一种来自Colletotrichum gloeosporioides SANK 21404的新型11β-羟类固醇脱氢酶1型抑制剂。

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摘要

Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis.
机译:发现了一种新的11β-羟类固醇脱氢酶1型(11beta-HSD1)抑制剂Colltotoic acid,并将其从生产的真菌Colletotrichum gloeosporioides SANK 21404的培养液中分离。通过数种光谱法确定其结构为新型的Acorene型倍半萜方法。使用改良的Mosher法和单晶X射线衍射分析法确定了草酸的绝对结构。

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