Anthelmintic Macrolactams from Nonomuraea turkmeniaca MA7381.

Ayers S; Zink DL; Powell JS; Brown CM; Grund A; Genilloud O; Salazar O; Thompson D; Singh SB

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Anthelmintic Macrolactams from Nonomuraea turkmeniaca MA7381.

机译：土生Nonomuraea turkmeniaca MA7381的驱虫大内酰胺。

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A new macrolactam, fluvirucin B(0) (1), and two known macrolactams, Sch 38516/fluvirucin B(1) (2) and Sch 39185/fluvirucin B(3) (3), have been isolated from an acetone extract of a strain of Nonomuraea turkmeniaca. These compounds were isolated by bioassay-guided fractionation as part of our search for new anthelmintics. The structures of these compounds were elucidated by comparison of their NMR and MS data to those of previously reported fluvirucins, and confirmed by 2D-NMR. 1~3 exhibited in vitro activity (EC(90) <1.0~1.7 mug/ml) against Haemonchus contortus larvae, but were ineffective in reducing worm counts in vivo against Heligmosomoides polygyrus in mice at 50 mg/kg dosed intramuscularly.

机译：从丙酮的丙酮提取物中分离出一种新的大内酰胺氟维卢星B（0）（1）和两个已知的大内酰胺Sch 38516 /氟维卢星B（1）（2）和Sch 39185 /氟维卢星B（3）（3）。土库曼诺氏菌的一种。这些化合物是通过生物测定引导分离法分离的，这是我们寻找新驱虫药的一部分。通过将它们的NMR和MS数据与先前报道的氟病毒素进行比较，阐明了这些化合物的结构，并通过2D-NMR进行了确认。 1〜3表现出对捻转血矛线虫幼虫的体外活性（EC（90）<1.0〜1.7杯/毫升），但在肌肉内剂量为50 mg / kg的小鼠体内，对减少多虫类Heligmosomoides polygyrus的蠕虫计数无效。

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《The Journal of Antibiotics: An International Journal》 |2008年第2期|共4页
作者
Ayers S; Zink DL; Powell JS; Brown CM; Grund A; Genilloud O; Salazar O; Thompson D; Singh SB;
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正文语种 eng
中图分类药学;药品;
关键词
Nuclear Magnetic Resonance; in vivo; Sch 38516; Sch 39185; 核磁共振;

机译：Nuclear Magnetic Resonance;in vivo;Sch 38516;Sch 39185;核磁共振;

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1. Anthelmintic Macrolactams from Nonomuraea turkmeniaca MA7381. [J] . Ayers S, Zink DL, Powell JS, The Journal of Antibiotics: An International Journal . 2008,第2期

机译：土生Nonomuraea turkmeniaca MA7381的驱虫大内酰胺。
2. Nonomuraea guangzhouensis sp. Nov., and Nonomuraea harbinensis sp. Nov., two novel actinomycetes isolated from soil [J] . WangS., LiuC., ZhangY., Antonie van Leeuwenhoek: Journal of Microbiology and serology . 2014,第1期

机译：广州野望藻和Nonomuraea harbinensis sp。 11月，从土壤中分离出两种新型放线菌
3. Nonomuraea sp. ID06-A0189 inulin fructotransferase (DFA III-forming): Gene cloning, characterization and conservation among other Nonomuraea species [J] . PudjirahartiS., OhtaniM., TakanoN., The Journal of Antibiotics: An International Journal . 2014,第2期

机译：野野菌属ID06-A0189菊粉果糖转移酶（DFA III形成）：其他野望菌属物种的基因克隆，鉴定和保存
4. Functional and structural analysis of unique adenylation enzyme IdnL7 involved in biosynthesis of macrolactam antibiotic incednine [C] . Jolanta Cieslak, Akimasa Miyanaga, Fumitaka Kudo 日本化学会春季年会講演予稿集 . 2018

机译：独特腺苷酸酶IDNL7涉及丙氨酸抗生素丙烯生物合成酶IDNL7的功能和结构分析
5. Aspiculuris tetraptera Ile do?al Enfekte Farelerde Rosmarinus oficinalis L. (Biberiye) Ve Rosmarinik Asidin Antihelmintik Etkisinin ara?t?r?lmas? =Investigating the anthelmintic effects of Rosmarinus officinalis L. and rosmarinic acid in mice naturally in [D] . Eylek, Buket. 2021

机译：含有Aspiculuris tetrapta，rosmarinus of inicinalis l.（迷迭香）和rosmarinic acid中间体甲吡喃酸的抗反生效果？ =研究自然rosmarinus Officinalis L.和rosmarinic酸的植物疗法
6. Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics [O] . Samantha A. Nixon, Claudia Welz, Debra J. Woods, 2020

机译：所有anthelmintics在哪里？新的Anthelmintics路径的挑战和机遇
7. Classification of Nonomuraea sp. ATCC 39727, an actinomycete that produces the glycopeptide antibiotic A40926, as Nonomuraea gerenzanensis sp. nov [O] . Dalmastri, Claudia, Gastaldo, Luciano, Marcone, GIORGIA LETIZIA, 2016

机译：Nonomuraea sp。的分类aTCC 39727，一种产生糖肽抗生素a40926的放线菌，如Nonomuraea gerenzanensis sp。十一月

Anthelmintic Macrolactams from Nonomuraea turkmeniaca MA7381.

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