In Vitro Antibacterial Activity of a New Cephalosporin, FR295389, against IMP-type Metallo-beta-lactamase-producers.

Takeda S; Ikeda F; Hatano K

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In Vitro Antibacterial Activity of a New Cephalosporin, FR295389, against IMP-type Metallo-beta-lactamase-producers.

机译：新的头孢菌素FR295389对IMP型金属β-内酰胺酶生产者的体外抗菌活性。

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FR295389 is a novel dihydroimidazopyrazolium cephalosporin. Although all previously reported cephalosporins had been ineffective against metallo-beta-lactamase (MBL)-producers, FR295389 showed moderate activity against these strains. The MIC values of FR295389 at which 50% and 90% of 21 clinical isolates of IMP-type MBL-producing Pseudomonas aeruginosa were inhibited were 8.0 and 32 mug/ml, respectively. The kinetic study of IMP-1 MBL showed that the K(m) and the k(cat) values against FR295389 were over 20-fold-higher and 12-fold-lower than those against ceftazidime, respectively, suggesting that FR295389 is a poor substrate for IMP-type MBL. This is the first report of a cephalosporin with activity against IMP-type MBL-producers.

机译：FR295389是新型的二氢咪唑并吡唑鎓头孢菌素。尽管以前报道的所有头孢菌素均对金属β-内酰胺酶（MBL）生产者无效，但FR295389对这些菌株显示中等活性。 FR295389的MIC值分别被抑制21个产生IMP的MBL的铜绿假单胞菌临床分离株的50％和90％，其MIC值分别为8.0和32马克/毫升。 IMP-1 MBL的动力学研究表明，抗FR295389的K（m）和k（cat）值分别比抗头孢他啶高20倍和低12倍，这表明FR295389较差IMP型MBL的基材。这是头孢菌素对IMP型MBL产生剂具有活性的首次报道。

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《The Journal of Antibiotics: An International Journal》 |2008年第1期|共4页
作者
Takeda S; Ikeda F; Hatano K;
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正文语种 eng
中图分类药学;药品;
关键词
Inosine Monophosphate; Cephalosporins; Endurance of activity; Antibacterial; 肌苷一磷酸; 头孢菌素类;

机译：Inosine Monophosphate;Cephalosporins;Endurance of activity;Antibacterial;肌苷一磷酸;头孢菌素类;

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1. In Vitro Antibacterial Activity of a New Cephalosporin, FR295389, against IMP-type Metallo-beta-lactamase-producers. [J] . Takeda S, Ikeda F, Hatano K The Journal of Antibiotics: An International Journal . 2008,第1期

机译：新的头孢菌素FR295389对IMP型金属β-内酰胺酶生产者的体外抗菌活性。
2. In vitro and in vivo antibacterial activity and pharmacokinetics of SC-002 and its derivative, SC-004: new oral cephalosporins. [J] . Nagate T, Akashi T, Numata K, Chemotherapy: International Journal of Experimental and Clinical Chemotherapy . 2001,第3期

机译：SC-002及其衍生物SC-004的体外和体内抗菌活性和药代动力学：新型口服头孢菌素。
3. In vitro and in vivo antibacterial activities of S-1090, a new oral cephalosporin, in the fields of obstetrics and gynecology. [J] . Mikamo H, Kawazoe K, Sato Y, Chemotherapy: International Journal of Experimental and Clinical Chemotherapy . 1998,第3期

机译：S-1090（一种新型口服头孢菌素）在妇产科领域的体外和体内抗菌活性。
4. In Vitro Assessment of Antibacterial Activity and Cytotoxicity of Silver Contained Antibacterial HA Coating Material [C] . Ziyuan Zhu, Fuqiang Zhang, Youtao Xie, Eco-materials processing and design X . 2009

机译：含银抗菌HA涂层材料的抗菌活性和细胞毒性的体外评估
5. In vitro Antioxidant and Antibacterial Activity of Twenty-One Northern Ontario Medicinal Plants. [D] . Hassan, Mohammad Haider. 2013

机译：二十一种北安大略药用植物的体外抗氧化和抗菌活性。
6. In vitro and in vivo antibacterial activities of E1077 a novel parenteral cephalosporin with a broad antibacterial spectrum. [O] . K Hata, M Otsuki, T Nishino 1992

机译：E1077（一种具有广泛抗菌谱的新型肠胃外头孢菌素）的体外和体内抗菌活性。
7. In vitro and in vivo antibacterial activities of E1077, a novel parenteral cephalosporin with a broad antibacterial spectrum. [O] . Hata, K, Otsuki, M, Nishino, T 1992

机译：E1077（一种具有广泛抗菌谱的新型肠胃外头孢菌素）的体外和体内抗菌活性。
8. Comparative In vitro Activity of Five Cephalosporin Antibiotics Against Salmonellae. [R] . Strausbaugh, L. J., Mikhail, I. A., Edman, D. C. 1977

机译：五种头孢菌素类抗生素对沙门氏菌的体外活性比较。

In Vitro Antibacterial Activity of a New Cephalosporin, FR295389, against IMP-type Metallo-beta-lactamase-producers.

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