Salinisporamycin, a novel metabolite from Salinispora arenicola. (corrected).

Matsuda S; Adachi K; Matsuo Y; Nukina M; Shizuri Y

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Salinisporamycin, a novel metabolite from Salinispora arenicola. (corrected).

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Salinisporamycin, a novel metabolite from Salinispora arenicola. (corrected).

机译：Salinisporamycin是一种新的代谢产物，来自salinispora arenicola。（已更正）。

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A new rifamycin antibiotic, salinisporamycin (1), has been isolated from a culture of a marine actinomycete. The producing organism was identified as Salinispora arenicola [corrected] on the basis of the 16S rRNA sequence. High-resolution FAB-MS established the molecular formula of 1 as C(33)H(43)NO(9). The planar structure of 1 was elucidated by NMR spectral analysis including COSY, heteronuclear single quantum coherence and heteronuclear multiple bond correlation. The relative stereochemistry of 1 was determined on the basis of rotating frame nuclear Overhauser effect spectroscopy. In addition, the solvatochromic behavior of 1 was investigated by measuring the UV spectra. This compound inhibited the growth of A549 cells, the human lung adenocarcinoma cell line, with an IC(50) value of 3 microg ml(-1), and also showed antimicrobial activity.

机译：从海洋放线菌的培养物中分离出一种新的利福霉素抗生素，盐霉素（1）。根据16S rRNA序列将生产生物鉴定为沙门氏菌[Salinispora arenicola [更正]。高分辨率FAB-MS建立1的分子式为C（33）H（43）NO（9）。通过NMR光谱分析阐明了1的平面结构，包括COSY，异核单量子相干性和异核多键相关性。 1的相对立体化学是根据旋转框架核Overhauser效应光谱学确定的。另外，通过测量UV光谱研究了1的溶剂变色行为。该化合物抑制人肺腺癌细胞系A549细胞的生长，IC（50）值为3 microg ml（-1），并且还显示出抗菌活性。

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《The Journal of Antibiotics: An International Journal》 |2009年第9期|共8页
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Matsuda S; Adachi K; Matsuo Y; Nukina M; Shizuri Y;
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中图分类药学;
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1. Salinisporamycin, a novel metabolite from Salinispora arenicola. (corrected). [J] . Matsuda S, Adachi K, Matsuo Y, The Journal of Antibiotics: An International Journal . 2009,第9期

机译：Salinisporamycin是一种新的代谢产物，来自salinispora arenicola。（已更正）。
2. Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. [J] . Asolkar RN, Kirkland TN, Jensen PR, The Journal of Antibiotics: An International Journal . 2010,第1期

机译：菌霉素，抗生素对来自海洋放射素孢子孢柳菌的海洋滑落菌氏菌葡萄球菌的抗生素。
3. Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. [J] . Asolkar RN, Kirkland TN, Jensen PR, The Journal of Antibiotics: An International Journal . 2010,第1期

机译：菌霉素，抗生素对来自海洋放射素孢子孢柳菌的海洋滑落菌氏菌葡萄球菌的抗生素。
4. GENOME-SCALE RECONSTRUCTION OF SALINISPORA TROPICA METABOLISM; MICROBIAL ENGINEERING AND ITS APPLICATIONS IN SECONDARY METABOLITE PRODUCTION [C] . B.A. Andrews, C.A. Contador, V.D. Saucedo, Microbial engineering . 2018

机译：基因组大规模重建沙门氏菌的代谢微生物工程及其在二次代谢产物生产中的应用
5. The Comparative Genomics of Salinispora and the Distribution and Abundance of Secondary Metabolite Genes in Marine Plankton. [D] . Penn, Kevin Matthew. 2012

机译：Salinispora的比较基因组学以及海洋浮游生物中次生代谢物基因的分布和丰度。
6. LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola [O] . Utpal Bose, Amitha K. Hewavitharana, Yi Kai Ng, 2015

机译：基于LC-MS的沙门氏菌海洋细菌次级代谢产物和抗生素生产的代谢组学研究
7. LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola [O] . Utpal Bose, Amitha K. Hewavitharana, Yi Kai Ng, 2015

机译：基于LC-ms的代谢产物研究海洋细菌次生代谢产物和抗生素在salinispora arenicola中的应用
8. Virulence and Antigenic Properties of 'Rickettsia tsutsugamushi' in a Naturally Infected Laboratory Colony of 'Leptotrombidium (Leptotrombidium)' arenicola. [R] . Robinson, D. M., Roberts, L. W., Dohany, A. L., 1977

机译：“恙虫病立克次体”在自然感染的'Leptotrombidium（Leptotrombidium）'arenicola实验室群中的毒力和抗原性质。

Salinisporamycin, a novel metabolite from Salinispora arenicola. (corrected).

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