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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Xylarinols A and B, two new 2-benzoxepin derivatives from the fruiting bodies of Xylaria polymorpha.
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Xylarinols A and B, two new 2-benzoxepin derivatives from the fruiting bodies of Xylaria polymorpha.

机译：Xylarinols A和B，两种来自Xylaria polymorpha子实体的新的2-苯并二氧杂庚烯衍生物。

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摘要

Basidiomycetes, as decomposers of forest litter, represent an ecologically important group of organisms in the environment, and are known to produce a large variety of secondary metabolites with unique chemical structures and interesting biological activities.1 The genus Xylaria has been known to produce a diverse class of bioactive compounds, including cytochalasin analogs with chemokine receptor antagonistic activity and cytotoxicity,2 multiplolides A, B and xylariamide A with antifungal activity,3,4 xylarenals A and B with neuropeptide Y receptor antagonistic activity5 and xyloketals A—E, acetylcholinesterase inhibitors.6 Earlier, we reported two antifungal substances, xylarinic acids A and B, from the methanolic extract of Xylaria polymorpha.7 Our ongoing investigation for novel chemical constituents from X. polymorpha has resulted in the isolation of two new 2-benzoxepin derivatives with ABTS (2,2'-azinobis(3-ethylben-zothiazoline-6-sulfonate)) radical scavenging activity. Benzoxepin is very rare in naturally occurring compounds. In this paper, we describe the isolation and structure determination of xylarinols A (1) and B (2), and their biological activity.
机译：枯草芽孢杆菌是森林凋落物的分解物，代表了环境中重要的生物有机体，并已知可产生具有独特化学结构和有趣生物活性的多种次生代谢产物。1已知木霉属可产生多种一类生物活性化合物，包括具有趋化因子受体拮抗活性和细胞毒性的细胞松弛素类似物，具有抗真菌活性的多倍体类化合物A，B和木糖酰胺A，3、4具有神经肽Y受体拮抗活性的木糖醛类A和B，木酮缩醛A-E，乙酰胆碱酯酶抑制剂。 6之前，我们报道了多形木糖醇的甲醇提取物中的两种抗真菌物质，木糖酸A和B。7我们正在对多形木糖的新化学成分进行研究，结果分离出了两种新的带有ABTS的2-苯并二恶英衍生物（ 2,2'-叠氮基双（3-乙基-苯并噻唑啉-6-磺酸根）自由基清除活性。苯并氧杂庚酮在天然化合物中非常罕见。在本文中，我们描述了木糖醇A（1）和B（2）的分离和结构测定及其生物学活性。

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