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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators.
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Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators.

机译：avilamycin A的产生受两个转录激活因子AviC1和AviC2的调节。

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摘要

Streptomycetes are typical soil-dwelling bacteria with intricate morphological and biochemical differentiation of colonies, resulting in onset of secondary metabolite production. Compounds produced during these stages of differentiation comprise nearly two-thirds of bioactive molecules synthesized by microorganisms, including antibiotics, antitumor agents and immunosuppressants.1,2 The biosynthesis of antibiotics and other secondary metabolites is controlled by interactions of both global and pathway-specific regulators. However, in all cases, the influence of the environment is reflected by the activity of pathway-specific regulatory genes, which are located within a biosynthetic gene cluster and which control the expression of bio-synthetic genes.3 On account of high structural and functional similarity, such regulators were grouped into two families, namely Streptomyces antibiotics regulatory proteins (SARP), mostly found within the aromatic polyketides clusters, and large ATP-binding regulators of LuxR family (LAL), controlling the production of macrolides and glycopeptides. Recent efforts in cloning and characterization of biosynthetic gene clusters for new groups of secondary metabolites revealed novel classes of transcriptional factors that differ from typical SARPs or LAL representatives.
机译：链霉菌是典型的居住在土壤中的细菌，具有复杂的菌落形态和生化分化，可导致次级代谢产物的产生。在分化的这些阶段产生的化合物包括微生物合成的近三分之二的生物活性分子，包括抗生素，抗肿瘤剂和免疫抑制剂1,2。 。但是，在所有情况下，环境影响都通过位于生物合成基因簇中并控制生物合成基因表达的途径特异性调控基因的活性来反映。3由于具有较高的结构和功能类似地，此类调节剂分为两个家族，即链霉菌抗生素调节蛋白（SARP）（主要在芳香族聚酮化合物簇中发现）和LuxR家族的大型ATP结合调节剂（LAL），控制大环内酯和糖肽的产生。在新的次生代谢物组的生物合成基因簇的克隆和表征方面的最新努力揭示了不同于典型SARPs或LAL代表的新型转录因子。

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