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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Lactariolines A and B: New guaiane sesquiterpenes with a modulatory effect on interferon-γ production from the fruiting bodies of Lactarius hatsudake
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Lactariolines A and B: New guaiane sesquiterpenes with a modulatory effect on interferon-γ production from the fruiting bodies of Lactarius hatsudake

机译：Lactariolines A和B：新的愈创甘油醚倍半萜对帽菇乳杆菌子实体产生的干扰素γ具有调节作用

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摘要

Interferons (IFNs) are cytokines that have a complex and central role in the resistance of mammalian hosts to pathogens. IFN-gamma, also known as immune or type IIIFN, is a homodimer produced predominantly by activated T cells and natural killer (NK) cells, and it is crucial for innate and adaptive immunity against intracellular pathogens and for tumor control. Aberrant IFN-gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, however, most importantly, IFN-gamma possesses immunostimulatory and immunomodulatory effects. Lactarius hatsudake, belonging to the family Russulaceae of Basi-diomycete, is a common edible mushroom widely distributed in Korea, China, Japan, Europe and North America, and biological activity (for example, antitumor and antiviral effects) of L. hatsudake has been reported. Previous investigation on the bioactive constituents of L. hatsudake resulted in the isolation of several ergosterol derivatives6 and azulene pigments.
机译：干扰素（IFN）是在哺乳动物宿主对病原体的抗性中具有复杂且重要作用的细胞因子。 IFN-γ，也称为免疫或IIIFN，是主要由活化的T细胞和自然杀伤（NK）细胞产生的同型二聚体，对于抵抗细胞内病原体的先天性和适应性免疫以及控制肿瘤至关重要。异常的IFN-γ表达与多种自身炎症和自身免疫性疾病相关。 IFN-γ在免疫系统中的重要性部分源于其直接抑制病毒复制的能力，然而，最重要的是，IFN-γ具有免疫刺激和免疫调节作用。 s草乳杆菌属于巴西杆菌属的芸苔科，是一种常见的食用菌，广泛分布于韩国，中国，日本，欧洲和北美，并且hat草乳杆菌的生物学活性（例如抗肿瘤和抗病毒作用）一直在报告。先前对Hatsudake L.的生物活性成分的研究导致分离出了几种麦角固醇衍生物6和Azulene色素。

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