Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors

Xuhong Qian; Zhibin Li; Zhi Liu; Gonghua Song; Zhong Li

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Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors

机译：2-Aryliminooxazolidine衍生物作为海藻糖酶抑制剂的合成

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Trehalase (EC 3.2.1.28) is a very specific enzyme that hydrolyses trehalose to two glucose units~(1)) and is widely distributed in microorganisms, insects, plants and animals~(2)). The substrate trehalose is a main source of glucose in insects and fungi. In insects, trehalose is a principal blood sugar and is used to support various energy-requiring functions.~(3)) In fungi, trehalose is reported to participate in germination of ascospores~(4)). Therefore, the development of specific and potent trehalase inhibitors is of great interest for the control of insects and certain fungi.

机译：海藻糖酶（EC 3.2.1.28）是一种非常特殊的酶，可将海藻糖水解为两个葡萄糖单元（1）），并广泛分布于微生物，昆虫，植物和动物中（2））。底物海藻糖是昆虫和真菌中葡萄糖的主要来源。在昆虫中，海藻糖是主要的血糖，用于支持各种能量需求。〜（3））在真菌中，据报道海藻糖参与了子孢子的萌发〜（4））。因此，开发特异性和有效的海藻糖酶抑制剂对于控制昆虫和某些真菌具有极大的兴趣。

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《The Journal of Antibiotics: An International Journal》 |2001年第12期|共3页
作者
Xuhong Qian; Zhibin Li; Zhi Liu; Gonghua Song; Zhong Li;
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正文语种 eng
中图分类药学;药品;
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1. Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors [J] . Xuhong Qian, Zhibin Li, Zhi Liu, The Journal of Antibiotics: An International Journal . 2001,第12期

机译：2-Aryliminooxazolidine衍生物作为海藻糖酶抑制剂的合成
2. New synthesis and biological evaluation of uniflorine A derivatives: towards specific insect trehalase inhibitors [J] . Giampiero DAdamio, Antonella Sgambato, Matilde Forcella, Organic & biomolecular chemistry . 2015,第3期

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Syntheses of 2-Aryliminooxazolidine Derivatives as Trehalase Inhibitors

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