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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Reveromycin A Inhibits Antigen Receptor-mediated Antigen Presentation by B Lymphoma Cells via Its Effect on Intracellular Trafficking of the Antigen
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Reveromycin A Inhibits Antigen Receptor-mediated Antigen Presentation by B Lymphoma Cells via Its Effect on Intracellular Trafficking of the Antigen

机译：Reveromycin A抑制B淋巴瘤细胞通过抗原受体介导的抗原呈递作用，对抗原的细胞内转运

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摘要

Reveromycin A (Rev. A) is an inhibitor of epidermal growth factor-dependent cell growth that is produced from the culture broth of an actinomycete strain. Rev. A was assessed for its ability to regulate antigen (Ag) presentation by A20-HL B lymphoma cells bearing trinitrophenyl (TNP)-specific surface IgM (sIgM) to cloned T cells specific for OVA_(323 approx 339)/I-A~d. Rev. A-treatment inhibited the presentation of Ag internalized via sIgM, but not of Ag via fluid-phase pinocytosis. Rev. A-treatment decreased protein synthesis, but a similar decrease in protein synthesis by cycloheximide induced much less inhibition of sIgM-mediated Ag presentation. Rev. A-treatment decreased the rate of re-expression of sIgM in A20-HL cells, the amount of Ag internalized via sIgM during 3 hours of incubation, and the generation of antigenic peptides from TNP-OVA internalized via sIgM. Rev. A-treatment was suggested to affect intracellular trafficking from early endosomes into late endocytic compartments of Ag internalized via sIgM. Rev. A might provide a useful tool for studying intracellular transport of Ag, especially Ag internalized via sIgM.
机译：Reveromycin A（Rev. A）是一种由放线菌菌株的培养液产生的表皮生长因子依赖性细胞生长的抑制剂。 Rev. A评估了具有三硝基苯基（TNP）特异性表面IgM（sIgM）的A20-HL B淋巴瘤细胞对特异于OVA_（323约339）/ IA〜d的克隆T细胞的调节抗原（Ag）呈递的能力。 Rev. A处理可抑制通过sIgM内在化的Ag的呈递，但不会抑制通过液相Pinocytosis的Ag的呈递。 Rev. A处理降低了蛋白质的合成，但环己酰亚胺对蛋白质合成的类似减少却导致了对sIgM介导的Ag呈递的抑制作用要小得多。 Rev. A处理降低了A20-HL细胞中sIgM的重新表达速度，孵育3小时内通过sIgM内在的Ag量以及通过sIgM内在的TNP-OVA抗原肽的生成。建议使用Rev A处理来影响从早期内体到sIgM内在化的Ag的晚期内吞区室的细胞内运输。版本A可能为研究Ag的细胞内转运提供有用的工具，尤其是通过sIgM内在化的Ag。

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