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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Acremonidins,new polyketide-derived Antibiotics Producedby Acremonium sp.,LL-Cyan 416
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Acremonidins,new polyketide-derived Antibiotics Producedby Acremonium sp.,LL-Cyan 416

机译:Acremonium sp。,LL-Cyan 416生产的新的聚酮化合物衍生的Acremonidins抗生素

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摘要

Acremonidins Aapprox E(1approx 5) were produced by fermentation of Acremonium sp.,LL-Cyan 416,in heterogeneous phases.the structures of these compounds,containign a bridging keto group,were determined by spectroscopic analysis.Acremonidins A and B showed moderate activity against Gram-posiftive bactria,including the methicillin-resistant staphylococci and vancomycin-resistant enterococci.Seletive acylations of acremonidin B afforded ester derivatives 6approx9 that exhibited improved antibacterial activity.
机译:顶头孢霉菌素Aapprox E(1约5)是通过Acremonium sp。,LL-Cyan 416的异相发酵而产生的,通过光谱分析确定了这些化合物的结构,包含一个桥接的酮基。对抗革兰氏阳性细菌,包括耐甲氧西林的葡萄球菌和耐万古霉素的肠球菌。丙烯醛B的选择性酰化作用提供了酯衍生物6approx9,其抗菌活性得到改善。

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