Structure Determination of Glycinocins A to D, Futher Evidence for the Cyclic Structure of the Amphomycin Antibiotics

Fangming Kong; Guy T.Carter

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Structure Determination of Glycinocins A to D, Futher Evidence for the Cyclic Structure of the Amphomycin Antibiotics

机译：甘霉素A到D的结构测定，进一步证明两性霉素抗生素的环状结构

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Four novel cyclolipopeptides, glycinocins A to D, were isolated from the fermentation broth of an unidentified terrestrial Actinomycete species. These compounds were separated and purified from the fermentation broth by 1-butanol extraction, followed by repeated reversed-phase HPLC. Their structures were elucidated by spectroscopic and chemical degradation studies. The absolute configuration of the amino acid residues was determined using Marfey's methodology. The glycinocin antibiotics are structurally related to amphomycin that was originally reported as a linear lipopeptide with C-terminal diketopiperazine moiety. Our degradation study of the glycinocin antibiotics also yielded diketopiperazine-containing fragments, but these have bee show to be hydrolytic by-products generated by condensation of the pipecolinic acid and diamino propionic acid residues.

机译：从一个未知的陆生放线菌物种的发酵液中分离出了四个新的环脂肽，甘氨酸霉素A至D。这些化合物通过1-丁醇萃取从发酵液中分离和纯化，然后重复反相HPLC。通过光谱和化学降解研究阐明了它们的结构。氨基酸残基的绝对构型是使用Marfey方法确定的。甘氨酸抗生素在结构上与两性霉素有关，该两性霉素最初被报道为具有C端二酮哌嗪部分的线性脂肽。我们对甘氨酸抗生素的降解研究也产生了含二酮哌嗪的片段，但这些蜜蜂已证明是由胡椒酸和二氨基丙酸残基缩合产生的水解副产物。

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《The Journal of Antibiotics: An International Journal》 |2003年第6期|共8页
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Fangming Kong; Guy T.Carter;
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中图分类药学;
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1. Structure Determination of Glycinocins A to D, Futher Evidence for the Cyclic Structure of the Amphomycin Antibiotics [J] . Fangming Kong, Guy T.Carter The Journal of Antibiotics: An International Journal . 2003,第6期

机译：甘霉素A到D的结构测定，进一步证明两性霉素抗生素的环状结构
2. Ab initio and Vibrational Predissociation Studies on Methylammonium-(Water)₄ Complex: Evidence for Multiple Cyclic and Non-cyclic Hydrogen-bonded Structures [J] . Doo Wan Boo, Kwang-Yon Kim, Ung-In Cho, Bulletin of the Korean Chemical Society . 2006,第12期

机译：甲基铵-（水）_{4 配合物的从头算和振动预离解研究：多个环状和非环状氢键结构的证据}
3. Determination of the absolute stereostructure of a cyclic azobenzene from the crystal structure of the precursor containing a heavy element [J] . Reji Thomas, Nobuyuki Tamaoki Beilstein journal of organic chemistry. . 2016,第1期

机译：从含有重元素的前体的晶体结构确定环状偶氮苯的绝对立体结构
4. Structure-Antibacterial Activity Relationship of Cyclic Lipodepsipeptide Antibiotic Fusaricidin A [C] . Nina Bionda, Daniela Treitl, Maciej Stawikowski American Peptide Symposium . 2009

机译：循环脂质肽抗生素Fusaricidin A的结构 - 抗菌活性关系
5. Cyclic lipodepsipeptides as lead structures for the discovery of new antibiotics. [D] . Bionda, Nina. 2013

机译：环状脂肽作为先导结构，用于发现新的抗生素。
6. Determination of the absolute stereostructure of a cyclic azobenzene from the crystal structure of the precursor containing a heavy element [O] . Reji Thomas, Nobuyuki Tamaoki 2016

机译：从含有重元素的前体的晶体结构确定环状偶氮苯的绝对立体结构
7. Determination of the absolute stereostructure of a cyclic azobenzene from the crystal structure of the precursor containing a heavy element [O] . Reji Thomas, Nobuyuki Tamaoki 2016

机译：从含有重元素的前体的晶体结构确定环状偶氮苯的绝对立体结构
8. DENDRAL-64 - A system for computer construction, enumeration and notation of organic molecules as tree structures and cyclic graphs. Part II - Topology of cyclic graphs Interim report [R] . Lederberg, J. 1965

机译：DENDRaL-64 - 用于计算机构造，枚举和有机分子符号的系统，如树结构和循环图。第II部分 - 循环图的拓扑中期报告

Structure Determination of Glycinocins A to D, Futher Evidence for the Cyclic Structure of the Amphomycin Antibiotics

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