Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.

Koizumi Y; Arai M; Tomoda H; Omura S

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.

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Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.

机译：真菌生物碱Fungerin通过抑制微管聚合作用将细胞周期停滞在M期。

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A fungal alkaloid fungerin was found to arrest the cell cycle of Jurkat cells at the G2/M phase, then to induce apoptosis. Immunoblotting showed that fungerin led to hyperphosphorylation for Cdc25C and dephosphorylation of Cdc2, indicating that the compound arrests the cell cycle at the M phase. Moreover, fungerin inhibited the polymerization of microtubule proteins in vitro. It was concluded that fungerin arrests the cell cycle at the M phase through inhibition of microtubule polymerization.

机译：发现一种真菌生物碱真菌素在G2 / M期阻止Jurkat细胞的细胞周期，然后诱导细胞凋亡。免疫印迹表明，真菌素导致Cdc25C的过度磷酸化和Cdc2的去磷酸化，表明该化合物使细胞周期停滞在M期。此外，真菌素在体外抑制微管蛋白的聚合。结论是，真菌素通过抑制微管聚合而将细胞周期停滞在M期。

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《The Journal of Antibiotics: An International Journal》 |2004年第7期|共6页
作者
Koizumi Y; Arai M; Tomoda H; Omura S;
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正文语种 eng
中图分类药学;
关键词
Cell Cycle; Polymerization; Microtubules; Psychological inhibition; 细胞周期; 微管;

机译：Cell Cycle;Polymerization;Microtubules;Psychological inhibition;细胞周期;微管;

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1. Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization. [J] . Koizumi Y, Arai M, Tomoda H, The Journal of Antibiotics: An International Journal . 2004,第7期

机译：真菌生物碱Fungerin通过抑制微管聚合作用将细胞周期停滞在M期。
2. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one induces cell cycle arrest and apoptosis in HeLa cells by preventing microtubule polymerization. [J] . Kim SY, An JM, Lee HG, Biochemical and Biophysical Research Communications . 2011,第2期

机译：1H-（1,2,4）oxadiazolo（4,3-a）quinoxalin-1-one通过阻止微管聚合诱导HeLa细胞的细胞周期停滞和凋亡。
3. 1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one induces cell cycle arrest and apoptosis in HeLa cells by preventing microtubule polymerization. [J] . Kim SY, An JM, Lee HG, Biochemical and Biophysical Research Communications . 2011,第2期

机译：1H-（1,2,4）oxadiazolo（4,3-a）quinoxalin-1-one通过阻止微管聚合诱导HeLa细胞的细胞周期停滞和凋亡。
4. Growth Inhibition and Cell Cycle Arrest of Kappa-Selenocarrageenan and Paclitaxel on HepG2 Cells [C] . Na Ling International Conference on Materials for Environmental Protection and Energy Application . 2012

机译：Kappa-selenocarrageenan和紫杉醇对HepG2细胞的生长抑制和细胞周期骤停
5. The Effects of Taxotere and Ixabepilone on Mitotic Arrest, Apoptosis, Inhibition of Proliferation and Inhibition of Microtubule Dynamic Instability in Class III β-tubulin Knockdown MCF7 Cells [D] . Smiyun, Gregoriy Mikhaylovich 2012

机译：紫杉醇和伊沙贝比隆对III类β-微管蛋白敲低MCF7细胞有丝分裂阻滞，凋亡，增殖的抑制和微管动态不稳定性的影响。
6. Phenolic Compounds Isolated from Caesalpinia coriaria Induce S and G2/M Phase Cell Cycle Arrest Differentially and Trigger Cell Death by Interfering with Microtubule Dynamics in Cancer Cell Lines [O] . Jessica Nayelli Sánchez-Carranza, Laura Alvarez, Silvia Marquina-Bahena, 2017

机译：从Ca草中分离出的酚类化合物通过干扰癌细胞系中的微管动力学差异性地诱导S和G2 / M期细胞周期停滞并触发细胞死亡。
7. Oxaline, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of tubulin polymerization [O] . Koizumi Yukio, Arai Masayoshi, Tomoda Hiroshi, 2004

机译：Oxaline，一种真菌生物碱，通过抑制微管蛋白的聚合而使细胞周期停滞在M期

Fungerin, a fungal alkaloid, arrests the cell cycle in M phase by inhibition of microtubule polymerization.

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