...
首页> 外文期刊>The Journal of Antibiotics: An International Journal >Anti-MRSA drug use and antibiotic susceptibilities of MRSA at a university hospital in Japan from 2007 to 2011
【24h】

Anti-MRSA drug use and antibiotic susceptibilities of MRSA at a university hospital in Japan from 2007 to 2011

机译:2007年至2011年日本某大学医院的抗MRSA药物使用和MRSA的抗生素敏感性

获取原文
获取原文并翻译 | 示例
           

摘要

The purpose of this study is to examine the use of anti-methicillin- resistant Staphylococcus aureus (MRSA) drugs, such as vancomycin (VCM), teicoplanin (TEIC), arbekasin (ABK) and linezolid (LZD), and the antibiotic susceptibilities of MRSAs in Kobe University Hospital. We investigated MRSA isolation and use of anti-MRSA drugs and susceptibilities of MRSA, using linear regression analysis, from 2007 to 2011, and checked for correlation between the use of these drug and the antibiotic susceptibilities of MRSA. The overall monthly isolation rates of MRSA decreased from a mean of 84.8% in 2007 to 70.0% in 2011 (r=0.946, P=0.015, b=-0.220), and the monthly isolation rate of MRSA in inpatients decreased from a mean of 78.6% in 2007 to 57.7% in 2011 (r=0.952, P=0.012, b=-0.160). From 2007 to 2011, VCM consumption significantly increased (r=0.916, P=0.029, b=0.055), whereas TEIC and LZD use remained stable during the study period. In addition, ABK use significantly decreased from 23.8 defined daily dose (DDD) per 1000 patient-days in 2007 to 5.2 DDD per 1000 in 2011 (r=0.902, P=0.036, b=-0.216). Susceptibility rates of MRSA were almost 100% to TEIC and VCM. The rates of MRSA to ABK and LZD significantly increased (r=0.959, P=0.010, b=2.137 for ABK and r=0.933, P=0.020, b=3.111 for LZD). In conclusion, our findings indicated a decreased MRSA isolation rate and the effective use of anti-MRSA drugs (VCM, TEIC, ABK and LZD), and improved susceptibility rates to anti-MRSA drugs, suggesting the possibilities that appropriate and early use of anti-MRSA drugs may cause the decrease of MRSA isolation.
机译:这项研究的目的是检查抗甲氧西林金黄色葡萄球菌(MRSA)药物的使用,例如万古霉素(VCM),替考拉宁(TEIC),阿贝卡星(ABK)和利奈唑胺(LZD),以及对它们的抗生素敏感性神户大学医院的MRSA。我们使用线性回归分析研究了2007年至2011年的MRSA分离和抗MRSA药物的使用以及MRSA的敏感性,并检查了这些药物的使用与MRSA的抗生素敏感性之间的相关性。 MRSA的总体每月隔离率从2007年的平均值84.8%下降到2011年的70.0%(r = 0.946,P = 0.015,b = -0.220),住院患者的MRSA每月隔离率也从平均值2007年为78.6%,2011年为57.7%(r = 0.952,P = 0.012,b = -0.160)。从2007年到2011年,VCM消耗量显着增加(r = 0.916,P = 0.029,b = 0.055),而TEIC和LZD的使用在研究期间保持稳定。此外,ABK的使用从2007年的每千个患者日23.8规定的日剂量(DDD)显着降低至2011年的每千个患者5.2 DDD(r = 0.902,P = 0.036,b = -0.216)。 MRSA对TEIC和VCM的敏感性接近100%。 MRSA对ABK和LZD的比率显着增加(对于ABK,r = 0.959,P = 0.010,b = 2.137,对于LZD,r = 0.933,P = 0.020,b = 3.111)。总之,我们的发现表明降低了MRSA分离率并有效使用了抗MRSA药物(VCM,TEIC,ABK和LZD),并且提高了对抗MRSA药物的敏感性,这提示了适当和早期使用抗MRSA药物的可能性。 -MRSA药物可能会导致MRSA分离度降低。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号