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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology
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Christopher Walsh: Pioneer and innovator in antibiotic and natural product chemical biology

机译：Christopher Walsh：抗生素和天然产物化学生物学的先驱和创新者

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For over four decades, Christopher Walsh has bridged the disciplines of Chemistry and Biology to greatly advance our understanding of primary and secondary metabolism. The application of this body of work in medicine has been profound, especially influencing (but not limited to) the fields of antibiotic discovery, cancer chemotherapy and immune suppression. Walsh began his independent career at the Massachusetts Institute of Technology (MIT) formally in the Department of Chemistry, but also associated with the Department of Biology.1 This was an unusual arrangement at the time, but presaged the development of the multidisciplinary field that we now call Chemical Biology. Indeed Walsh has been at the forefront of this area inspiring legions along the way. At MIT he authored the first of his three books, Enzymatic Reaction Mechanisms? A hefty tome that was the 'gateway drug' (to abuse a term) for many students, including myself, to the application of chemical thought and instinct to biological reactions. Its clear writing style and logical flow was to be a hallmark of Walsh's over 800 publications. The work art MIT included pioneering research on cofactor enzymology, including enzymes requiring flavin and pyridoxal phosphate among others. Out of these interests came efforts to development and characterize 'suicide substrates' that exploit enzyme mechanisms to uncover reactive enzyme-inactivating species, many of which find use in drug discovery. Walsh also took on the challenge of department Chair at that time, initiating what was to become a long-standing parallel career in university administration.
机译：在过去的四十年中，克里斯托弗·沃尔什（Christopher Walsh）在化学和生物学学科之间架起了桥梁，极大地增进了我们对一级和二级代谢的理解。该工作体系在医学​​上的应用非常广泛，特别是影响（但不限于）抗生素发现，癌症化学疗法和免疫抑制等领域。沃尔什（Walsh）正式在麻省理工学院（MIT）的化学系开始他的独立职业生涯，但也与生物学系有联系。1这在当时是一种不寻常的安排，但预示着我们在多学科领域的发展现在称为化学生物学。的确，沃尔什（Walsh）一直在这一领域的前沿，激发着众多军团。在麻省理工学院，他撰写了三本书中的第一本，《酶促反应机制？对于许多学生，包括我本人，在化学思维的应用和对生物反应的直觉上，这是一个“门户药物”（滥用术语）的沉重篇幅。沃尔什（Walsh）的800多种出版物均以其鲜明的写作风格和顺畅的逻辑性而著称。麻省理工学院的工作领域包括辅因子酶学的开创性研究，其中包括需要黄素和磷酸吡ido醛的酶。这些兴趣来自于开发和表征“自杀底物”的工作，这些底物利用酶机制发现反应性酶失活物种，其中许多发现可用于药物开发。当时，Walsh还接受了系主任的挑战，开始了后来成为大学管理领域长期并行的职业。

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