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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Antimicrobial potency of single and combined mupirocin and monoterpenes, thymol, menthol and 1,8-cineole against Staphylococcus aureus planktonic and biofilm growth
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Antimicrobial potency of single and combined mupirocin and monoterpenes, thymol, menthol and 1,8-cineole against Staphylococcus aureus planktonic and biofilm growth

机译：莫匹罗星和单萜，单萜类，百里酚，薄荷醇和1,8-桉树脑对金黄色葡萄球菌浮游生物膜和生物膜生长的抗菌作用

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摘要

Staphylococcus aureus is one of the most commonly isolated microbes in chronic rhinosinusitis (CRS) that can be complicated due to the formation of a staphylococcal biofilm. In this study, we investigated antimicrobial efficacy of single mupirocin and three types of monoterpenes (thymol, menthol and 1,8-cineole) as well as mupirocin-monoterpene combinations against S. aureus ATCC 29213 and 5 methicilin-resistant S. aureus strains (MRSA) grown in planktonic and biofilm form. MIC against planktonic bacteria as well as minimum biofilm-eliminating concentrations (MBECs) and minimum biofilm inhibitory concentrations (MBICs) were determined by TTC and MTT reduction assay, respectively. The MICs of mupirocin (0.125-0.156 mu g ml(-1)) were three orders of magnitude lower than the MICs of monoterpenes, which were as follows: thymol (0.250-0.375 mg ml(-1)) > menthol (1 mg ml(-1)) > 1,8-cineole (4-8 mg ml(-1)). Mupirocin-monoterpene combinations showed indifferent effect as compared with MICs of single substances. Mupirocin (0.016-2 mg ml(-1)) failed to destroy the biofilm. The MBECs of thymol and menthol were two- to sixfold higher than their MICs, while 1,8-cineole exerted a weak antibiofilm effect with MBECs 16- to 64-fold higher than MICs. Mixture of mupirocin and 1,8 cineole exerted a potentiated biofilm-eliminating effect, mupirocin-menthol showed antagonism, while effect of thymol-mupirocin mixture was inconclusive. MBICs of antimicrobials were close to their MICs, except 1,8-cineole, MBIC was about three- to fivefold higher. Dominant synergy was observed for mixtures of mupirocin and menthol or thymol, whereas mupirocin-1,8-cineol exerted an indifferent or additive biofilm inhibitory effect. Particular combinations of mupirocin and the monoterpenes could be applied in CRS therapy in order to eliminate or prevent bacterial biofilm growth.
机译：金黄色葡萄球菌是慢性鼻－鼻窦炎（CRS）中最常见的分离细菌之一，由于形成了葡萄球菌生物膜而变得复杂。在这项研究中，我们研究了单种莫匹罗星和三种类型的单萜（百里酚，薄荷醇和1,8-桉树脑）以及莫匹罗星-单萜组合对金黄色葡萄球菌ATCC 29213和5种耐甲氧西林金黄色葡萄球菌菌株（ MRSA）以浮游生物膜和生物膜的形式生长。分别通过TTC和MTT还原测定法确定了针对浮游细菌的MIC以及最小生物膜消除浓度（MBEC）和最小生物膜抑制浓度（MBIC）。莫匹罗星的MIC（0.125-0.156μg ml（-1））比单萜的MIC低三个数量级：百里酚（0.250-0.375 mg ml（-1））>薄荷醇（1 mg ml（-1））> 1,8-桉树脑（4-8 mg ml（-1））。与单一物质的MIC相比，莫匹罗星-单萜组合显示出不同的作用。莫匹罗星（0.016-2 mg ml（-1））未能破坏生物膜。百里香酚和薄荷醇的MBEC比其MIC高2至6倍，而1,8-桉树脑的抗生物膜作用较弱，MBEC比MIC高16至64倍。莫匹罗星和1,8桉树脑的混合物具有增强的生物膜消除作用，莫匹罗星-薄荷醇显示拮抗作用，而百里酚-莫匹罗星混合物的作用尚无定论。抗菌药物的MBIC接近其MIC，除了1,8-桉树脑外，MBIC大约高三到五倍。观察到莫匹罗星与薄荷醇或百里香酚的混合物具有明显的协同作用，而莫匹罗星-1,8-木酚则具有无差别或加成的生物膜抑制作用。莫匹罗星和单萜的特殊组合可用于CRS治疗，以消除或预防细菌生物膜的生长。

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