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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Isolation of growth inhibitors of the snow rot pathogen Pythium iwayamai from an arctic strain of Trichoderma polysporum
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Isolation of growth inhibitors of the snow rot pathogen Pythium iwayamai from an arctic strain of Trichoderma polysporum

机译：从北极多孢木霉菌的北极菌株中分离出雪腐病原体腐霉Pythium iwayamai的生长抑制剂

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摘要

Growth inhibitors were isolated from an arctic strain of Trichoderma polysporum, and the structures were elucidated and the in vitro inhibitory effects of these compounds against Pythium iwayamai were investigated. Eleven compounds were isolated; four showed a concentration-dependent growth-inhibitory effect against P. iwayamai. None of these compounds have been reported previously as substances with antimicrobial activity against P. iwayamai. One of these four compounds inhibited the growth of the pathogen at 33 mu g ml(-1) concentration during a 15-day incubation at 20 degrees C. This effect was comparable to that of chloroneb (1: 1,4-dichloro-2,5-dimethoxybenzene), a fungicide with activity against P. iwayamai. Thus, the results of the present study show that the arctic strain of T. polysporum can be an effective source of antibiotics with activity against the snow rot pathogen, P. iwayamai.
机译：从北极木霉菌的北极菌株中分离了生长抑制剂，并阐明了其结构，并研究了这些化合物对岩梨腐霉的体外抑制作用。分离出11种化合物。有四个显示出对P. iwayamai的浓度依赖性生长抑制作用。这些化合物以前均未报道为对伊维氏疟原虫具有抗菌活性的物质。这四种化合物中的一种在20摄氏度下孵育15天期间以33μg ml（-1）的浓度抑制了病原体的生长。这种作用与chloroneb（1：1,4-dichloro-2 ，5-二甲氧基苯），一种对伊维氏疟原虫有活性的杀菌剂。因此，本研究的结果表明，多孢孢子虫的北极菌株可以是一种有效的抗生素源，对雪腐病原体伊瓦玛伊病菌具有活性。

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