Preparation and Antimicrobial Activity of Micacocidin

KOBAYASHI SHINOBU; IKENISHI YUJI; TAKINAMI YOSHIHIKO; TAKEMA MORIO; SUN WEI-YIN; INO AKIRA; HAYASE YOSHIO

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Preparation and Antimicrobial Activity of Micacocidin

机译：米卡考丁的制备及其抑菌活性

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Micacocidin (3), a Zn-free derivative of micacocidin A (1), was prepared to evaluate its antimicrobial activity in comparison with 1 and to obtain a starting material for chemical modification of 1. The structure of 3, quite unlike those of any previously known antimicrobial agents, was elucidated by 1-D and 2-d homonuclear and heteronuclear NMR and mass spectroscopy.Micacocidin (3) thus prepared exhibited weak or no antibacterial activity except against Mycoplasma species,i.e. 3 showed stronger activity than 1. It is noteworthyl that 3 displayed high activity against fungi such as Candida, Aspergillus and Trichophyton species.

机译：制备了MICACOCIDIN（3），即MICACocidin A（1）的无锌衍生物，以评估其抗菌活性（与1相比），并获得用于化学修饰的起始原料1。3的结构与任何其他化合物的结构都非常不同通过1-D和2-d同核和异核NMR和质谱法阐明了以前已知的抗菌剂。如此制得的Micacocidin（3）除针对支原体物种外，均表现出弱或无抗菌活性。 3显示出比1更强的活性。值得注意的是，3显示出对诸如念珠菌，曲霉和毛癣菌等真菌的高活性。

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来源
《The Journal of Antibiotics: An International Journal》 |2000年第5期|共8页
作者
KOBAYASHI SHINOBU; IKENISHI YUJI; TAKINAMI YOSHIHIKO; TAKEMA MORIO; SUN WEI-YIN; INO AKIRA; HAYASE YOSHIO;
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正文语种 eng
中图分类药学;药品;
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机译：米卡考丁的制备及其抑菌活性
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Preparation and Antimicrobial Activity of Micacocidin

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