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首页> 外文期刊>The Journal of Antibiotics: An International Journal >cis-Fumagillin, a New Methionine Aminopeptidase (type 2) Inhibitor Produced by Penicillium sp. F2757
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cis-Fumagillin, a New Methionine Aminopeptidase (type 2) Inhibitor Produced by Penicillium sp. F2757

机译：顺式富马洁林，一种由青霉属sp生产的新型蛋氨酸氨基肽酶（2型）抑制剂。 F2757

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摘要

Selective inhibition against the yeast MetAP2 (methiomine aminopeptidase type 2) was detected in the fermentation broth of a fungus F2757 that was later identified as Penicillium janczewskii. A new compound cis-fumagillin methyl ester (1) was isolated from the diazomethane treated fermentation extracts togethe with the known compound fumagillin methyl ester (2). The cis-fumagillin methyl ester, a stereoisomer of fumagillin methyl ester at the C2'-C3' position of the aliphatic side chain, selectively inhibited growth of the map 1mutant yeast strain (MetAP1 deletion strain) at a concentration as low as 1 ng. However, the wild type yeast w303 and the mulant map2 (MetAP2 deleted) strains were resistant up to 10 #mu#g of the compound. In enzyme experiments, compound 112F^P^19L V.53 N.8 Aug. 2000^15F^P^3L TQ^16F^P^14L Kwon,,Ju-Yong^17F^P^155LKorea Research Institute of Bioscience and Biotechnology, 52-Eundong, Yusong, Tajon 305-333, Republic of Korea 1402 S. Grand Blvd., St. Louis MO 63104, USA
机译：在真菌F2757的发酵液中检测到对酵母MetAP2（甲硫氨酸氨基肽酶2型）的选择性抑制，该真菌后来被鉴定为青霉。从重氮甲烷处理过的发酵提取物中分离出一种新的化合物顺式烟曲霉素甲酯（1），与已知的化合物烟曲霉素甲酯（2）共同作用。顺式-富马吉林甲酯（fumagillin甲酯在脂肪族侧链C2'-C3'位置的立体异构体）以低至1 ng的浓度选择性抑制图1突变酵母菌株（MetAP1缺失菌株）的生长。然而，野生型酵母w303和mulant map2（缺失MetAP2）菌株对高达10＃μg的化合物具有抗性。在酶实验中，化合物112F ^ P ^ 19L V.53 N.8 2000年8月8日^ 15F ^ P ^ 3L TQ ^ 16F ^ P ^ 14L Kwon，Ju-Yong ^ 17F ^ P ^ 155L韩国生物科学研究所大韩民国大松市裕松市52-Eundong 305-333，美国密苏里州圣路易斯市1402 S. Grand Blvd.，美国63104

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