F-12509A,a New Sphingosine Kinase Inhibitor, Produced by a Discomycete

KONO KEITA; TANAKA MASAHIRO; OGITA TAKESHI; HOSOYA TSUYOSHI; KOHAMA TAKAFUMI

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F-12509A,a New Sphingosine Kinase Inhibitor, Produced by a Discomycete

机译：F-12509A，一种新的鞘氨醇激酶抑制剂，由Discomycete生产

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In the course of our screening for inhibitors of sphingosine kinase, we found an active compound from a culture broth of a discomycete, Trichopezizella barbata SANK 25395. The structure of the compound, named F-12509A, was elucidated by a combination of spectroscopic analyses, to be a new sesquiterpene quinone consisting of a drimane moiety and a dihydroxybenzoquinone. Enzyme kinetic analyses showed that F-12509A inhibits sphingosine kinase activity in a competitive manner with respect to sphingosine, with a K_i value of 18 #mu#M.

机译：在筛选鞘氨醇激酶抑制剂的过程中，我们从圆盘菌Tribatpezizella barbata SANK 25395的培养液中发现了一种活性化合物。该化合物的结构F-12509A通过光谱分析的组合得以阐明，成为一种新的倍半萜醌，它由drimane部分和二羟基苯醌组成。酶动力学分析表明，F-12509A以相对于鞘氨醇竞争的方式抑制鞘氨醇激酶活性，K_i值为18＃mu＃M。

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《The Journal of Antibiotics: An International Journal》 |2000年第5期|共8页
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KONO KEITA; TANAKA MASAHIRO; OGITA TAKESHI; HOSOYA TSUYOSHI; KOHAMA TAKAFUMI;
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正文语种 eng
中图分类药学;药品;
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1. F-12509A,a New Sphingosine Kinase Inhibitor, Produced by a Discomycete [J] . KONO KEITA, TANAKA MASAHIRO, OGITA TAKESHI, The Journal of Antibiotics: An International Journal . 2000,第5期

机译：F-12509A，一种新的鞘氨醇激酶抑制剂，由Discomycete生产
2. S-15183a and B,New Sphingosine Kinase Inhibitors,Produced by a Fungus [J] . Keita Kono, Masahiro Tanaka, Yasunori Ono, The Journal of Antibiotics: An International Journal . 2001,第5期

机译：S-15183a和B，新型鞘氨醇激酶抑制剂，由真菌生产
3. Characterization of B-5354c, a New Sphingosine Kinase Inhibitor, Produced by a Marine Bacterium [J] . Kono Keita The Journal of Antibiotics: An International Journal . 2000,第8期

机译：海洋细菌产生的新型鞘氨醇激酶抑制剂B-5354c的表征
4. A System For Sphingosine-1-Phosphate Delivery Using The Enzyme Sphingosine Kinase [C] . M. M. Kaneda, S.K. Hughes, D.L. Elbert Society for Biomaterials Transactions of the 30th Annual Meeting amp; Exposition vol.28: New Applications and Technologies; 20050427-30; Memphis,TN(US) . 2005

机译：使用鞘氨醇激酶的鞘氨醇-1-磷酸传递系统。
5. Development of Sphingosine Kinase 1 Inhibitors for the Treatment of Cancer Progression [D] . Kennedy, Andrew John 2011

机译：鞘氨醇激酶1抑制剂的开发，用于治疗癌症进展
6. Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway in Disease: Review of Sphingosine Kinase Inhibitors [O] . K. Alexa Orr Gandy, Lina M. Obeid -1

机译：靶向鞘氨酸激酶/鞘氨酸三磷酸磷酸磷酸术：鞘氨醇激酶抑制剂的综述
7. B-5354a, b and c, New Sphingosine Kinase Inhibitors, Produced by a Marine Bacterium. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Structure Determination. [O] . KEITA KONO, MASAHIRO TANAKA, TADAYOSHI MIZUNO, 2000

机译：B-5354A，B和C，新的鞘氨酸激酶抑制剂，由海洋细菌产生。分类，发酵，分离，物理化学性质和结构测定。

F-12509A,a New Sphingosine Kinase Inhibitor, Produced by a Discomycete

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