NEW DIHYDRO AND TETRAHYDRO DERIVATIVES OF DESMYCOSIN .3. THE OPENING OF OXIRANE RING OF 12,13-EPOXYDESMYCOSIN

Naranda A.; Kelneric Z.; Lopotar N.

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NEW DIHYDRO AND TETRAHYDRO DERIVATIVES OF DESMYCOSIN .3. THE OPENING OF OXIRANE RING OF 12,13-EPOXYDESMYCOSIN

机译：地塞米松的新的二羟基和四羟基衍生物.3。 12,13-环氧木霉菌素的环氧乙烷环的打开

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Opening the oxirane ring of 12,13-epoxydesmycosin dimethylacetal (1) by catalytic hydrogenation gave the 10,11-dihydro-12,13-epoxy derivative (3) as the main product. Reductive oxirane cleavage was accomplished with dissolved metal (Zn) giving the 10,13-dihydro-13-hydroxy compound (6). Mild acid hydrolysis of 6 gave expected 10,13-dihydro-13-hydroxydesmycosin (8), but hydrolysis of 3, under the same conditions, gave three tautomeric desepoxy products. [References: 12]

机译：通过催化氢化打开12，13-环氧去粘菌素二甲基缩醛（1）的环氧乙烷环，得到10，11-二氢-12，13-环氧衍生物（3）为主要产物。用溶解的金属（Zn）完成还原性环氧乙烷裂解，得到10,13-二氢-13-羟基化合物（6）。 6的轻度酸水解可得到预期的10,13-二氢-13-羟基desmycosin（8），而在相同条件下3的水解可得到三种互变异构的脱环氧产物。 [参考：12]

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《The Journal of Antibiotics: An International Journal》 |1997年第10期|共6页
作者
Naranda A.; Kelneric Z.; Lopotar N.;
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正文语种 eng
中图分类药学;药品;
关键词
Tylosin;

机译：泰乐菌素;

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1. NEW DIHYDRO AND TETRAHYDRO DERIVATIVES OF DESMYCOSIN .3. THE OPENING OF OXIRANE RING OF 12,13-EPOXYDESMYCOSIN [J] . Naranda A., Kelneric Z., Lopotar N. The Journal of Antibiotics: An International Journal . 1997,第10期

机译：地塞米松的新的二羟基和四羟基衍生物.3。 12,13-环氧木霉菌素的环氧乙烷环的打开
2. Benzimidazole condensed ring systems: new synthesis and antineoplastic activity of substituted 3,4-dihydro- and 1,2,3,4-tetrahydro-benzo(4,5)imidazo(1,2-a)pyrimidine derivatives. [J] . Abdel-monem-Abdel-hafez A Archives of pharmacal research . 2007,第6期

机译：苯并咪唑稠环系统：取代的3,4-二氢-和1,2,3,4-四氢-苯并（4,5）咪唑并（1,2-a）嘧啶衍生物的新合成和抗肿瘤活性。
3. Benzimidazole condensed ring systems: New synthesis and antineoplastic activity of substituted 3,4-dihydro- and 1,2,3,4-tetrahydro-benzo [4,5]imidazo[1,2-a]pyrinnidine derivatives [J] . Atef Abdel-monem Abdel-hafez Archives of Pharmacal Research . 2007,第6期

机译：苯并咪唑稠环系统：取代的3,4-二氢和1,2,3,4-四氢-苯并[4,5]咪唑并[1,2-a]嘧啶衍生物的新合成和抗肿瘤活性
4. HIGHLY SELECTIVE AND FACILE SYNTHESIS OF DIHYDRO- AND TETRAHYDRO-PYRIDINE DICARBOXYLIC ACID DERIVATIVES USING ELECTROREDUCTION AS A KEY STEP [C] . Ikuzo Nishiguchi, Yoshio Kita, Hirofumi Maekawa, Fifth International Manuel M.Baizer Symposium in Honor of Professor Jean Michel Saveant at the 201st Meeting of the Electrochemical Society Centennial Meeting May 12-17, 2002 Philadelphia, PA, USA . 2002

机译：以电还原为关键步骤的高选择性，轻松合成二羟基和四羟基吡啶二羧酸衍生物
5. 1. Synthesis of C-glycoside sulfones via oxirane-thirane exchange. 2. Preparation of sialic acid derivatives amenable to solid-phase synthesis. 3. Conformational analysis of complex polysaccharides. [D] . Flaherty, Terrence Michael. 1997

机译：1.通过环氧乙烷-丙氨酸交换合成C-糖苷砜。 2.制备适于固相合成的唾液酸衍生物。 3.复杂多糖的构象分析。
6. Antibacterial activity of dihydro-13-oxazine derivatives condensed with aromatic rings in positions 5 6 [O] . J. B. Chylińska, M. Janowiec, T. Urbański 1971

机译：在5、6位与芳香环缩合的二氢-13-恶嗪衍生物的抗菌活性
7. New Derivatives of Tylosin. IV. Dihydro and Tetrahydro Desmycosin Oximes. [O] . AMALIA NARANDA, NEVENKA LOPOTAR 1999

机译：泰洛斯的新衍生物。 IV。二氢和四氢脱霉菌素肟。

NEW DIHYDRO AND TETRAHYDRO DERIVATIVES OF DESMYCOSIN .3. THE OPENING OF OXIRANE RING OF 12,13-EPOXYDESMYCOSIN

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