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首页> 外文期刊>The Journal of Antibiotics: An International Journal >The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption.
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The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption.

机译：精神三胺天然产物对革兰氏阳性细菌具有抗菌活性，并通过膜破坏起作用。

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摘要

Antibiotic therapy places intense selection pressure on bacteria that inevitably leads to the emergence of resistance,1 and thus the need to continually identify and develop new antibiotics. Secondary metabolite natural products have been, and seem likely to continue to be, the best source of antibacterial agents, providing the vast majority of therapeutics actually used in the clinic.2 As a result, it is of great interest to examine newly identified secondary metabolites for their potential antibacterial activity. There is a growing appreciation that plants provide a unique source of diverse secondary metabolites with potentially important biological activities, with one of the most promising classes being the indole alkaloids.3 One such indole alkaloid natural product is psychotrimine (1, Figure 1), which was isolated in 2004 from leaves of the South American shrub Psychotria rostrata, and has attracted considerable interest from the synthetic and medicinal chemistry communities owing to its unusual connectivity between tryptamine subunits.
机译：抗生素疗法对细菌施加了巨大的选择压力，不可避免地导致了耐药性的出现1，因此需要不断地鉴定和开发新的抗生素。次生代谢产物天然产物一直是并且似乎仍将是最佳的抗菌剂来源，提供了临床上实际使用的绝大多数疗法。2因此，检查新发现的次生代谢产物引起了极大的兴趣。具有潜在的抗菌活性。人们日益认识到，植物提供了具有潜在重要生物活性的多种次生代谢产物的独特来源，其中最有前途的一类是吲哚生物碱。3这类吲哚生物碱天然产物是精神三胺（1，图1）， 2004年从南美灌木Psychotria rostrata的叶子中分离得到，由于其在色胺酮亚基之间的不寻常连通性，引起了合成和药物化学界的极大兴趣。

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