The genus Actinoallomurus and some of its metabolites.

Pozzi R; Simone M; Mazzetti C; Maffioli S; Monciardini P; Cavaletti L; Bamonte R; Sosio M; Donadio S

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The genus Actinoallomurus and some of its metabolites.

机译：猕猴桃属及其一些代谢产物。

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In the search for novel antibiotics, natural products continue to represent a valid source of bioactive molecules. During a program aimed at identifying previously unreported taxa of actinomycetes as potential source of novel compounds, we isolated hundreds of different representatives of a new group, initially designated as 'Alpha' and independently described as Actinoallomurus. We report on a PCR-specific method for the detection of this taxon, on appropriate growth conditions and on a pilot-screening program on 78 strains. The strains produce antibacterial or antifungal compounds at a relatively high frequency. Four strains were characterized in further detail: one produced the aromatic polyketide benanomicin B and its dexylosyl derivative; a second strain produced N-butylbenzenesulfonamide; a third strain was an efficient converter of soymeal isoflavonoids from soymeal constituents; and a fourth strain produced several coumermycin-related aminocoumarins, with coumermycin A2 as the major peak, and with some new congeners as minor components of the complex. These data suggest that Actinoallomurus strains possess several pathways for secondary metabolism and represent an attractive source in the search for novel antibiotics.

机译：在寻找新型抗生素时，天然产物继续代表生物活性分子的有效来源。在旨在识别以前未报告的放线菌类群作为新化合物潜在来源的计划中，我们分离了一个新小组的数百个不同代表，这些代表最初被命名为“ Alpha”，并被独立地描述为放线菌。我们报告了一种检测该类群的PCR特异性方法，适当的生长条件以及对78个菌株的中试筛选计划。该菌株以相对较高的频率产生抗菌或抗真菌化合物。进一步详细表征了四株菌株：一株产生了芳香族聚酮化合物贝那霉素B及其右旋糖基衍生物。第二株产生N-丁基苯磺酰胺;第三株是从豆粕成分中高效转化豆粕异黄酮的化合物。第四株产生几种与香豆素相关的氨基香豆素，其中以香豆素A2为主要峰，并以一些新的同源物作为该复合物的次要成分。这些数据表明放线放线菌菌株具有若干次生代谢途径，并且代表了寻找新型抗生素的诱人来源。

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《The Journal of Antibiotics: An International Journal》 |2011年第1期|共7页
作者
Pozzi R; Simone M; Mazzetti C; Maffioli S; Monciardini P; Cavaletti L; Bamonte R; Sosio M; Donadio S;
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中图分类药学;
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1. 猕猴桃属美味猕猴桃和毛花猕猴桃种间杂交的胚胎学和胚援救 [J] . 母锡金, 王文玲植物学报：英文版 . 1990,第006期
2. The genus Actinoallomurus and some of its metabolites. [J] . Pozzi R, Simone M, Mazzetti C, The Journal of Antibiotics: An International Journal . 2011,第1期

机译：猕猴桃属及其一些代谢产物。
3. Isolation of actinomycetes from the root of the plant, Ophiopogon japonicus, and proposal of two new species, Actinoallomurus liliacearum sp. nov. and Actinoallomurus vinaceus sp. nov. [J] . KoyamaR., MatsumotoA., InahashiY., The Journal of Antibiotics: An International Journal . 2012,第7期

机译：从植物，蛋白核酸卟啉粳稻根系中分离放线菌，两种新种，Actinoallomurus Liliacemum Sp。 11月。和Actinoallomurus vinaceus sp。 11月。
4. Anaerobic oxidation of n-alkenes by sulphate-reducing bacteria from the genus Desulfatiferula: n-ketones as potential metabolites. [J] . Grossi V, Cravo Laureau C, Rontani JF, Research in Microbiology . 2011,第9期

机译：来自Desulfatiferula属的硫酸盐还原细菌对正构烯烃的厌氧氧化：正构酮为潜在的代谢产物。
5. Mild steel passivation and depassivation in simulated concrete pore solution containing bacteria metabolites. [C] . Enrico Volpi, Matteo Stefanoni, Andrea Olietti, Corrosion and surface engineering . 2014

机译：在含有细菌代谢产物的模拟混凝土孔隙溶液中，低碳钢会发生钝化和钝化。
6. St. Thomas Aquinas on the Principle that the Maximum in any Genus is the Cause of All the Others in the Genus [D] . Factor, Daniel B. 2018

机译：圣托马斯阿奎那原则上，任何属的最大值都是属于属的所有其他人的原因
7. Novel Polyethers from Screening Actinoallomurus spp. [O] . Marianna Iorio, Arianna Tocchetti, Joao Carlos Santos Cruz, 2018

机译：筛选Actinoallomurus spp的新型聚醚。
8. The genus Nonomuraea: A review of a rare actinomycete taxon for novel metabolites. [O] . Sungthong R., Nakaew N. 2015

机译：Nonomuraea属：一种罕见的放线菌类新生物的分类。

The genus Actinoallomurus and some of its metabolites.

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