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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Aquastatin C, a new glycoaromatic derivative from Sporothrix sp. FN611.
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Aquastatin C, a new glycoaromatic derivative from Sporothrix sp. FN611.

机译：Aquastatin C，一种来自Sporothrix sp。的新的糖基芳香族衍生物。 FN611。

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Bacterial fatty acid synthesis (FAS) is an attractive antibacterial target, as FAS is organized differently in bacteria and mammals.1'2 Fatty acid biosynthesis in bacteria is crucial for the production of a number of lipid-containing components, including the cell membrane. The bacterial fatty acid system (FAS II) uses discrete monofunctional en2ymes, which operate in conjunction with acyl carrier protein (ACP)-associated substrates, whereas mammalian fatty acid synthase (FAS I) is mediated by a single multifunctional enzyme-ACP complex. The differences in prokaryote and eukaryote fatty acid biosynthesis provide an attractive opportunity for selective FAS II inhibition, which is a potential strategy for the development of antibacterial agents. Bacterial enoyl-ACP reductase, which catalyzes the final and rate-limiting step in type II FAS, has been validated as a novel target for the development of antibacterial drugs.
机译：细菌脂肪酸合成（FAS）是有吸引力的抗菌靶标，因为FAS在细菌和哺乳动物中的组织方式不同。1'2细菌中的脂肪酸生物合成对于生产包括细胞膜在内的许多含脂质成分至关重要。细菌脂肪酸系统（FAS II）使用离散的单功能酶，该酶与酰基载体蛋白（ACP）相关的底物结合使用，而哺乳动物脂肪酸合酶（FAS I）由单个多功能酶-ACP复合物介导。原核生物和真核生物脂肪酸生物合成的差异为选择性FAS II抑制提供了诱人的机会，这是开发抗菌剂的潜在策略。细菌烯酰-ACP还原酶催化II型FAS中的最终和限速步骤，已被证实是开发抗菌药物的新靶标。

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