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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.
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Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp.

机译：儿茶酚，一种新型的儿茶酚型抑制剂，可从链霉菌属物种中入侵肿瘤细胞。

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摘要

Microbial natural products represent the primary resource for drug discovery, accounting for > 20 000 bioactive compounds discovered to date.1 The majority of microbial drug discovery research has focused on actinomycetes, in particular strains of the chemically prolific genus Streptomyces. Drug discovery efforts from actinomycetes, however, have been in decline, in part because of the relatively high frequency of the isolation of known compounds. To overcome this problem, extensive attempts have been directed toward the development of effective strain selection methods to improve the efficiency of the discovery process. Sequence-based strain selection is one of the approaches to eliminate the strains which might be studied previously. Although it is not clear whether the phylogenic novelty is associated with the production ability of new compounds, recent studies have shown the occurrence of new metabolites in Streptomyces species that have a low 16S rRNA gene sequence homology to the known species.In our continuing investigation on chemical diversity within this group, a Streptomyces strain that shared a low 16S rRNA gene identity (96.3%) with the nearest type strain for S. albus was found to produce a new catecholate derivative, catechoserine (1), along with two known biosynthetically related metabolites, N,W-bis(2,3-dihydroxybenzoyl)-O-L-seryl L-serine (2) and N,N',N'-tris(2,3-dihydroxybenzoyl) -O-L-seryl-O-L-seryl L-serine (3) (Figure 1).
机译：微生物天然产物是药物发现的主要资源，占迄今为止发现的20 000多种生物活性化合物。1大多数微生物药物发现研究都集中在放线菌，特别是化学多产链霉菌属的菌株上。然而，放线菌的药物发现努力一直在下降，部分原因是已知化合物的分离频率相对较高。为了克服这个问题，已经进行了广泛的尝试，以开发有效的菌株选择方法以提高发现过程的效率。基于序列的菌株选择是消除可能先前研究过的菌株的方法之一。尽管尚不清楚系统进化的新颖性是否与新化合物的生产能力有关，但最近的研究表明链霉菌种中新代谢产物的发生与已知物种的16S rRNA基因序列同源性低。在这一组的化学多样性中，发现与链霉菌最近型菌株具有低16S rRNA基因同一性（96.3％）的链霉菌菌株可产生新的儿茶酚酸酯衍生物儿茶酚碱（1），以及两种已知的生物合成相关代谢产物，N，W-双（2,3-二羟基苯甲酰基）-OL-丝氨酸L-丝氨酸（2）和N，N'，N'-三（2,3-二羟基苯甲酰基）-OL-丝酰基-OL-丝氨酸L -丝氨酸（3）（图1）。

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