Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906

BoonlarppradabC.; SuriyachadkunC.; RachtaweeP.; ChoowongW.

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Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906

机译：Saccharosporones A，B和C，来自Saccharopolyspora sp。的细胞毒性抗疟古环素。密件抄送21906

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Three new angucyclinones, saccharosporones A, B and C, together with (+)-ochromycinone, (+)-rubiginone B 2, tetrangulol methyl ether and fujianmycin A, were obtained from fermentation of the terrestrial actinomycete of the genus Saccharopolyspora BCC 21906 isolated from a soil collected in Chanthaburi Province, Thailand. Structures of the new compounds and their relative configurations were assigned by NMR spectral data interpretation. Saccharosporones A and B exhibited antimalarial activity against Plasmodium falciparum K1 with IC 50 values of 4.1 and 3.9 μM. Both metabolites also possessed cytotoxic activities against cancer cell lines (KB, MCF-7 and NCI-H187) and nonmalignant Vero cell, while saccharosporone C only showed cytotoxic activity against NCI-H187.

机译：三种新的洋环霉素，糖孢子A，B和C以及（+）-邻苯二酚，（+）-Rubiginone B 2，四牛酚甲醚和福建霉素A，是从分离自Saccharospora BCC 21906的陆地放线菌的发酵中获得的。在泰国尖竹汶府收集的土壤。通过NMR光谱数据解释指定新化合物的结构及其相对构型。糖孢子A和B对恶性疟原虫K1表现出抗疟疾活性，IC 50值为4.1和3.9μM。两种代谢产物还具有针对癌细胞系（KB，MCF-7和NCI-H187）和非恶性Vero细胞的细胞毒活性，而糖孢子C仅对NCI-H187具有细胞毒活性。

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《The Journal of Antibiotics: An International Journal》 |2013年第6期|共5页
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BoonlarppradabC.; SuriyachadkunC.; RachtaweeP.; ChoowongW.;
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正文语种 eng
中图分类药学;
关键词
actinomycete; angucyclinone; antimalarial activity; cancer cell cytotoxicity; natural product; Saccharopolyspora sp.;

机译：放线菌;血管生成素;抗动物活性;癌细胞的细胞毒性;天然产物;糖多孢菌;

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1. Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906 [J] . BoonlarppradabC., SuriyachadkunC., RachtaweeP., The Journal of Antibiotics: An International Journal . 2013,第6期

机译：Saccharosporones A，B和C，来自Saccharopolyspora sp。的细胞毒性抗疟古环素。密件抄送21906
2. Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp. [J] . Bing Liu, Hartmut Laatsch, Hongpeng Wang, Marine Drugs . 2012,第3期

机译：Kiamycin，一种来自海洋链霉菌属的独特细胞毒性安古环素衍生物。
3. Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp. [J] . Bing Liu, Hartmut Laatsch, Hongpeng Wang, Marine Drugs . 2012,第3期

机译：Kiamycin，一种来自海洋链霉菌属的独特细胞毒性安古环素衍生物。
4. Phytochemistry Test and Cytotoxic Activity of Macroalgae Eucheuma sp. as a Growth Inhibitor of Breast MCF-7 Cancer Cells [C] . Elvira Lesmana, Ade Arsianti, Trivani Putri, International Symposium of Biomedical Engineering . 2019

机译：植物化学试验及大草原Eucheuma SP的细胞毒性活性。作为乳腺MCF-7癌细胞的生长抑制剂
5. I. Identification and structure elucidation of cytotoxic chamigrenes from the red alga Laurencia sp. II. Synthetic studies toward the sponge metabolite salicylihalamide A. [D] . Francisco, Maria Elena Yalong. 2000

机译：I.红藻劳伦西亚菌的细胞毒性变态毒素的鉴定和结构阐明。二。对海绵代谢产物水杨卤代酰胺A的合成研究。
6. Donghaecyclinones A–C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine Streptomyces sp. [O] . Munhyung Bae, Joon Soo An, Seong-Heon Hong, 2020

机译：Donghaecyclinones A–C：来自火山岛的海洋链霉菌属物种的新细胞毒性重排的Angucyclinones。
7. PM070747, a new cytotoxic angucyclinone from the marine-derived Saccharopolyspora taberi PEM-06-F23-019B [O] . Marta Pérez, Carmen Schleissner, Pilar Rodríguez, 2009

机译：PM070747，来自海洋衍生的Saccharopypora Taberi PEM-06-F23-019B的新细胞毒性旋蛋白

Saccharosporones A, B and C, cytotoxic antimalarial angucyclinones from Saccharopolyspora sp. BCC 21906

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