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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Protoilludane sesquiterpenoids as scaffold structures for new antimicrobials against Mannheimia haemolytica
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Protoilludane sesquiterpenoids as scaffold structures for new antimicrobials against Mannheimia haemolytica

机译：原illudaneane倍半萜作为支架结构的新型抗溶血曼海姆氏菌

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Research on the overall chemistry of basidiomycetes has led to the discovery of a wealth of secondary metabolites with rich variation of structures and novel carbon skeletons. Some compounds have found medical applications as lead structures for the development of pharmaceutical products, starting material for agrochemicals or antibiotics. Indeed, new antibiotics are continuously needed to counteract resistance of newly evolved pathogens and/or toxicity and allergic reactions of some of the current compounds.Recently, two novel protoilludane sesquiterpenoids, named pas-teurestins A and B (1 and 2 in Figure 1), have been isolated and characterized. Both compounds were obtained by fermentation of the basidiomycete Agrocybe aegerita and were reported to show strong and selective activity against two strains of Mannheimia haemolytica, a pathogen causing bovine respiratory disease. Particularly, M. haemolytica is the principal bacterium isolated from respiratory disease in feedlot cattle and represents an important component in enzootic pneumonia in neonatal calves.
机译：对担子菌的整体化学的研究导致发现了许多次级代谢产物，这些代谢产物具有丰富的结构变化和新颖的碳骨架。一些化合物已发现在医学上具有应用前景，可作为开发药物，农用化学品或抗生素的原料的主要结构。确实，不断需要新的抗生素来抵抗新近发展的病原体的耐药性和/或某些当前化合物的毒性和变态反应。最近，两种新的原illududane倍半萜类化合物称为pa-teurestins A和B（图1中的1和2）。 ，已被隔离和表征。这两种化合物都是通过发酵担子菌Agrocybe aegerita获得的，据报道对溶血曼恩海姆菌的两种菌株显示出强大的选择性活性，后者是引起牛呼吸道疾病的病原体。特别地，溶血支原体是从饲养场牛的呼吸道疾病中分离出的主要细菌，并且代表新生牛犊中的共生性肺炎的重要组成部分。

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