Dereplication of microbial extracts and related analytical technologies

ItoT.; MasubuchiM.

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Dereplication of microbial extracts and related analytical technologies

机译：重复提取微生物提取物和相关分析技术

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Natural products still continue to have an important role as a resource of various biologically active substances. Dereplication is a key process in natural product screening that analyzes the extracts of microbial fermentation broths or plant samples. In this review article, we describe and discuss the analytical techniques of dereplication and related technologies in the following sections: 1. Direct detection from microbial colonies. 2. Ultra high performance liquid chromatography (UHPLC)-MS profiling for library construction. 3. Micro-fractionation to identify active peaks. 4. Quantification of small-amount compounds. 5. Structure identification from small amounts. Using these techniques, the desired compound in the mixture library can be rapidly identified.

机译：天然产物作为各种生物活性物质的资源仍然继续发挥重要作用。去重复是天然产物筛选中的关键过程，其分析微生物发酵液或植物样品的提取物。在这篇综述文章中，我们在以下部分中描述和讨论重复复制的分析技术及相关技术：1.从微生物菌落中直接检测。 2.用于库构建的超高效液相色谱（UHPLC）-MS分析。 3.微分级以鉴定活性峰。 4.少量化合物的定量。 5.从少量识别结构。使用这些技术，可以快速识别混合物库中所需的化合物。

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《The Journal of Antibiotics: An International Journal》 |2014年第5期|共8页
作者
ItoT.; MasubuchiM.;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Dereplication; Microbial extract; Profiling; Quantification; Structure elucidation; UHPLC-MS;

机译：去重复;微生物提取;分析;定量;结构解析;UHPLC-MS;

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1. Dereplication of microbial extracts and related analytical technologies [J] . ItoT., MasubuchiM. The Journal of Antibiotics: An International Journal . 2014,第5期

机译：重复提取微生物提取物和相关分析技术
2. Analytic Strategies for Understanding Host-Associated Microbial Communities: Faster and cheaper DNA sequencing technologies combined with open-access analytic software packages are opening new vistas [J] . Kuczynski J., Knight R. Microbe: the news magazine of the American Society for Microbiology . 2011,第9期

机译：理解与宿主相关的微生物群落的分析策略：更快，更便宜的DNA测序技术与开放获取分析软件包相结合，开辟了新的前景
3. Rapid dereplication of microbial isolates using matrix-assisted laser desorption ionization time-of-flight mass spectrometry: A mini-review [J] . Doreen Huschek, Katja Witzel Journal of Advanced Research . 2019,第3期

机译：使用基质辅助激光解吸电离飞行时间质谱技术快速分离微生物分离株：小型回顾
4. Dereplication and profiling of marine bacteria by fatty acid analysis of crude extracts using fourier transform mass spectrometry [C] . David J. Bourne, Eliane Abou-Mansour, Russell T. Hill, International marine biotechnology conference . 1998

机译：使用傅里叶变换质谱法通过粗提物的脂肪酸分析对海洋细菌进行重复复制和分析
5. Capsaicinoid separation and the dereplication of natural product extracts. [D] . Constant, Howard Lorne. 1996

机译：辣椒素分离和天然产物提取物的去复制。
6. Decontamination pooling and dereplication of the 678 samples of the Marine Microbial Eukaryote Transcriptome Sequencing Project [O] . Mick Van Vlierberghe, Arnaud Di Franco, Hervé Philippe, 2021

机译：海洋微生物真核生物转录组测序项目678样品的净化汇集和含量
7. Screening and dereplication of microbial natural products extracts [O] . Månsson Maria, Vynne Nikolaj Grønnegaard, Wietz Matthias, 2011

机译：微生物天然产物提取物的筛选和去除
8. Standard Analytical Procedures of the NOAA (National Oceanic and Atmospheric Administration) National Analytical Facility, 1985-1986: Extractable Toxic Organic Compounds, Second Edition [R] . MacLeod, W. D. , Brown, D. W. , Friedman, A. J. , 1985

机译：NOaa（国家海洋和大气管理局）国家分析设施的标准分析程序，1985-1986：可萃取的有毒有机化合物，第二版

Dereplication of microbial extracts and related analytical technologies

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