首页> 外文期刊>The Journal of Antibiotics: An International Journal >Cytochalasins from cultures of endophytic fungus Phoma multirostrata EA-12
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Cytochalasins from cultures of endophytic fungus Phoma multirostrata EA-12

机译:来自内生真菌Phoma multirostrata EA-12的细胞松弛素

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摘要

Two new cytochalsians, multirostratin A (1) and 20-oxo-deoxaphomin (2), together with five known analogues (3-7), were obtained from the endophytic fungus Phoma multirostrata EA-12. The structures of 1 and 2 were elucidated by MS and 1D-and 2D-NMR spectroscopic data analyses, as well as by comparison of data with those of analogues reported in the literature. Compounds 1 and 2 showed moderate cytotoxicity against five tumor cell lines (HL-60, A-549, SMMC-7721, MCF-7 and SW-480).
机译:从内生真菌Phoma multirostrata EA-12获得了两个新的细胞噬菌素,multirostratin A(1)和20-氧-脱氧磷胺(2),以及五个已知的类似物(3-7)。通过MS和1D-和2D-NMR光谱数据分析以及通过将数据与文献中报道的类似物进行比较,阐明了1和2的结构。化合物1和2对五种肿瘤细胞系(HL-60,A-549,SMMC-7721,MCF-7和SW-480)显示出中等的细胞毒性。

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