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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Bioprobes for investigating mammalian cell cycle control [Review]
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Bioprobes for investigating mammalian cell cycle control [Review]

机译：用于研究哺乳动物细胞周期控制的生物探针[综述]

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摘要

Bioprobes are low molecular weight compounds which are useful for investigating mammalian cell functions. The use of bioprobes has substantially assisted the investigation of complex biochemical processes of the mammalian cell cycle. In this review, cell cycle inhibitors mainly isolated from the microorganism are described and their possibility as an antitumor agents is considered. Most cancer cells have some abnormality in the control mechanism of cell cycle progression. Cyclin-dependent kinases (Cdk), which are activated by the binding with the cyclin and simultaneously by the phosphorylation/dephosphorylation of itself, play important roles as engines in the cell cycle. Tubulins are considered to be one of the most important proteins of the cell division machinery. Therefore, Cdk inhibitors and tubulin binders are possible anticancer drugs. Since the function of proteins controlling the cell cycle is also regulated by phosphorylation and dephosphorylation, inhibitors of protein kinases and phosphatases are considered as possible an antitumor agents. We expect that some bioprobes will be developed for clinical use. [References: 62]
机译：生物探针是低分子量化合物，可用于研究哺乳动物的细胞功能。生物探针的使用大大有助于研究哺乳动物细胞周期复杂的生物化学过程。在这篇综述中，描述了主要从微生物中分离的细胞周期抑制剂，并考虑了其作为抗肿瘤剂的可能性。大多数癌细胞在细胞周期进程的控制机制中有一些异常。细胞周期蛋白依赖性激酶（Cdk）通过与细胞周期蛋白结合并同时通过自身的磷酸化/去磷酸化而激活，在细胞周期中起着重要的作用。微管蛋白被认为是细胞分裂机制中最重要的蛋白质之一。因此，Cdk抑制剂和微管蛋白粘合剂可能是抗癌药物。由于蛋白质控制细胞周期的功能也受到磷酸化和去磷酸化作用的调节，因此蛋白激酶和磷酸酶的抑制剂被认为是可能的抗肿瘤药物。我们期望一些生物探针将被开发用于临床。 [参考：62]

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