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首页> 外文期刊>The Journal of Antibiotics: An International Journal >3874 H1 and H3, novel antifungal heptaene antibiotics produced by Streptomyces sp. HAG 003874
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3874 H1 and H3, novel antifungal heptaene antibiotics produced by Streptomyces sp. HAG 003874

机译：3874 H1和H3，由链霉菌属（Streptomyces sp。）生产的新型抗真菌七烯类抗生素。 HAG 003874

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摘要

New antifungal antibiotics, designated as 3874 H1 and H3, were discovered in the fermentation broth of the strain Streptomyces sp. HAG 003874. The compounds were obtained as yellow powders after sequential purification by chromatography on MCI Gel CHP20P, Fractogel HW-40 and ODS reversed phase chromatography. On the basis of the results of spectroscopic analysis, it was found that 3874 H1, C58H86N2O18, MW 1098, belongs to the p-aminoacetophenone containing family of heptaene antibiotics, while 3874 H3, C57H87NO18, MW 1073, is a non-aromatic heptaene. In addition to these, a minor component, 3874 H2, C59H88N2O18, MW 1112, a N-methyl derivative of 3874 H1 has been detected. The structures were elucidated through mass spectral analyses and 1-D and 2-D homonuclear and heteronuclear NMR data. The outstanding physico-chemical feature of 3874 H3 is its improved solubility. The new heptaenes are potent antifungal compounds with broad activity spectra, encompassing dermatophytes, yeasts and filamentous fungi. [References: 22]
机译：在Streptomyces sp。菌株的发酵液中发现了新的抗真菌抗生素，命名为3874 H1和H3。 HAG003874。通过在MCI Gel CHP20P，Fractogel HW-40和ODS反相色谱上进行色谱纯化而得到的黄色粉末状化合物。根据光谱分析的结果，发现3874 H1，C58H86N2O18，MW 1098属于含有对氨基苯乙酮的七烯类抗生素，而3874 H3，C57H87NO18，MW 1073是非芳族七烯。除了这些，还检测到了次要成分3874 H2，C59H88N2O18，MW 1112和3874 H1的N-甲基衍生物。通过质谱分析以及一维和二维同核和异核NMR数据阐明了结构。 3874 H3的突出物理化学特征是其改善的溶解度。新的七烯类化合物是有效的抗真菌化合物，具有广泛的活性谱，涵盖了皮肤真菌，酵母菌和丝状真菌。 [参考：22]

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