Fungal Metabolites,Sorbicillinoid Polyketides and Their Effects on the Activation of Peroxisome Proliferator-activated Receptor gamma

Dongho Lee; Jeong Hyung Lee; Xing Fu Cai; Jin Chul Shin; Kyeong Lee

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Fungal Metabolites,Sorbicillinoid Polyketides and Their Effects on the Activation of Peroxisome Proliferator-activated Receptor gamma

机译：真菌代谢物，类青霉素类多酮化合物及其对过氧化物酶体增殖物激活受体γ活化的影响

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A new sorbicillinoid polyketide,dihydrotrichodimerol(2),along with known trichodimerol(1),and rezishanones C(3)and D(4)were isolated by bioassay-guided fractionation from an unidentified fungal strain.Dihydrotrichodimerol(2)specifically activated peroxisome proliferator-activated receptor gamma with an ED_(50)value of 80 ng/ml as measured by a transactivation assay using a chimeric hPPAR/GAL4 system without affecting peroxisome proliferator-activated receptors alpha and delta.On the other hand,compounds 1 and 2 suppressed the production of tumor necrosis factor-alpha and nitric oxide in LPS-stimulated RAW264.7 cells to a similar extent.

机译：通过生物测定指导分级分离从一个未知的真菌菌株中分离出一种新的山梨素类聚酮，二氢富集二聚醇（2），已知的甲壳二聚醇（1），和瑞香酮C（3）和D（4）。通过嵌合hPPAR / GAL4系统的反式激活测定法测得的ED_（50）值为80 ng / ml，而不会影响过氧化物酶体增殖物激活的受体α和δ。另一方面，化合物1和2被抑制LPS刺激的RAW264.7细胞中肿瘤坏死因子-α和一氧化氮的产生程度相似。

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《The Journal of Antibiotics: An International Journal》 |2005年第10期|共6页
作者
Dongho Lee; Jeong Hyung Lee; Xing Fu Cai; Jin Chul Shin; Kyeong Lee;
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正文语种 eng
中图分类药学;
关键词
sorbicillinoid; trichodimerol derivative; peroxisome proliferator-activated receptor gamma; tumor necrosis factor-alpha; nitric oxide;

机译：山梨醇;富二聚醇衍生物;过氧化物酶体增殖物激活受体γ;肿瘤坏死因子-一氧化氮;

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1. Fungal Metabolites,Sorbicillinoid Polyketides and Their Effects on the Activation of Peroxisome Proliferator-activated Receptor gamma [J] . Dongho Lee, Jeong Hyung Lee, Xing Fu Cai, The Journal of Antibiotics: An International Journal . 2005,第10期

机译：真菌代谢物，类青霉素类多酮化合物及其对过氧化物酶体增殖物激活受体γ活化的影响
2. Common polymorphisms of the peroxisome proliferator-activated receptor-gamma (Pro12Ala) and peroxisome proliferator-activated receptor-gamma coactivator-1 (Gly482Ser) and the response to pioglitazone in Chinese patients with type 2 diabetes mellitus. [J] . Hsieh MC, Lin KD, Tien KJ, Metabolism: Clinical and Experimental . 2010,第8期

机译：中国2型糖尿病患者过氧化物酶体增殖物激活受体-γ（Pro12Ala）和过氧化物酶体增殖物激活受体-γcoactivator-1（Gly482Ser）的常见多态性和对吡格列酮的反应。
3. Bioassay for the Identification of Natural Product-Based Activators of Peroxisome proliferator-Activated Receptor-gamma (PPAR gamma): The Marine Sponge Metabolite Psammaplin A Activates PPARy and Induces Apoptosis in Human Breast Tumor Cells [J] . Flor D.Mora, Deborah K.Jones, Prashant V.Desai, Journal of natural products . 2006,第4期

机译：用于鉴定过氧化物酶体增殖物激活的受体-γ（PPARγ）的天然产物为基础的激活剂的生物测定：海洋海绵代谢物Psammaplin A激活PPARy并诱导人乳腺癌细胞的凋亡。
4. Molecular Docking Studies of Flavonoids of Noni Fruit (Morinda citrifolia L.) to Peroxisome Proliferator-Activated Receptor-Gamma (PPAR_γ) [C] . Fikry Awaluddin, Andrianopsyah Mas Jaya Putra, Supandi International Conference on Computation for Science and Technology . 2015

机译：非果（Morinda Citrifolia L.）黄酮类化合物对过氧化物增殖物激活受体 - γ（PPAR_γ）的分子对接研究
5. Unraveling the effects of Thiazolidinediones and peroxisome proliferator-activated receptor gamma 1 on ovarian cancer. [D] . Al-Alem, Linah Fathi. 2011

机译：阐明噻唑烷二酮和过氧化物酶体增殖物激活的受体γ1对卵巢癌的影响。
6. Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes [O] . Raquel Villegas, Scott M. Williams, Yu-Tang Gao, -1

机译：过氧化物酶体增殖物激活受体（PPAR）和过氧化物酶体增殖物激活受体γ共激活因子1（PGC1）基因家族和2型糖尿病的遗传变异。
7. Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1 alpha, (PGC-1alpha), peroxisome proliferator-activated receptor gamma (PPARgamma) and estrogen related receptor alpha (ERRalpha) [O] . Kebbaj, Riad,, ANDREOLETTI, Pierre, El Hajj, Hammam,, 2015

机译：摩洛哥坚果油可防止内毒素引起的肝脏脂肪酸氧化和糖异生以及过氧化物酶体增殖物激活受体γcoactivator-1 alpha（PGC-1alpha），过氧化物酶体增殖物激活受体γ（PPARgamma）和雌激素相关受体α（ ERRalpha）

Fungal Metabolites,Sorbicillinoid Polyketides and Their Effects on the Activation of Peroxisome Proliferator-activated Receptor gamma

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