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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Effect of Cytogenin,a Novel Immunomodulator,on Streptozotocin-induced Diabetes in Mice
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Effect of Cytogenin,a Novel Immunomodulator,on Streptozotocin-induced Diabetes in Mice

机译:新型细胞免疫原细胞分裂素对链脲佐菌素诱发的糖尿病小鼠的作用

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摘要

The anti-diabetic effect of cytogenin was examined using streptozotocin-induced diabetes in mice.Cytogenin suppressed not only the increase of plasma glucose level but also the body weight reduction in diabetic mice.Histological examination of the pancreas taken from diabetic mice given cytogenin showed that cytogenin decreased the number of macrophages infiltrated into islet of pancreas.Further,cytogenin suppressed the nitric oxide generation by macrophages treated with lipopolysaccharide through decreasing of inducible nitric oxide synthase expression.Cytogenin suppressed interleukin-6 expression by macrophage treated with LPS,suggesting that the anti-diabetic activity of cytogenin might be partly attributed to the suppressive activity against nitric oxide generation.
机译:用链脲佐菌素诱导的糖尿病小鼠观察了细胞生成素的抗糖尿病作用,细胞生成素不仅抑制了糖尿病小鼠的血糖升高,而且减轻了体重的减轻;对服用细胞生成素的糖尿病小鼠的胰腺进行组织学检查表明:细胞分裂素通过减少诱导型一氧化氮合酶的表达来抑制脂多糖处理的巨噬细胞产生的一氧化氮的产生。细胞分裂素通过脂多糖处理的巨噬细胞来抑制白细胞介素6的表达,这表明其具有抗胰蛋白酶的作用。细胞分裂素的糖尿病活性可能部分归因于对一氧化氮生成的抑制活性。

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