Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929

M.Shibuya; Y.Sakano; Y.Ebizuka; B. B. Snider; H.Tomoda; S.Omura

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Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929

机译：修订的结构Epohelmins A和B分离为真菌菌株FKI-0929的羊毛甾醇合酶抑制剂

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The structures of epohelmins A and B isolated as lanosterol synthase inhibitors from a fungal strain FKI-0929 were revised to be lalpha-hydroxy-3alpha-(4'-oxoundec-(5'E)-enyl)-pyrrolizidine and lbeta-hydroxy-3akoga-(4'-oxoundec-(5'E)-enyl)-pyrrolizidine,respectively,by comparison with spectral data of synthetic compounds.

机译：从真菌菌株FKI-0929中分离为羊毛甾醇合酶抑制剂的内皮素A和B的结构被修改为lalpha-羟基-3alpha-（4'-oxoundec-（5'E）-烯基）-吡咯烷核苷和lbeta-羟基通过与合成化合物的光谱数据比较，分别确定了3akoga-（4'-oxoundec-（5'E）-烯基）-吡咯烷核苷。

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《The Journal of Antibiotics: An International Journal》 |2005年第9期|共3页
作者
M.Shibuya; Y.Sakano; Y.Ebizuka; B. B. Snider; H.Tomoda; S.Omura;
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正文语种 eng
中图分类药学;
关键词
epohelmin A; epohelmin B; l-hydroxy-3alpha-(4'-oxoundec-(5'E)-enyl)-pyrrolizidine; cholesterol biosynthesis; lanosterol synthase;

机译：内皮素A;内皮素B;1-羟基-3α-（4'-oxoundec-（5'E）-烯基）-吡咯烷核苷;胆固醇生物合成;羊毛甾醇合酶;

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1. Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929 [J] . M.Shibuya, Y.Sakano, Y.Ebizuka, The Journal of Antibiotics: An International Journal . 2005,第9期

机译：修订的结构Epohelmins A和B分离为真菌菌株FKI-0929的羊毛甾醇合酶抑制剂
2. Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pK(a). [J] . Brown GR, strazeneca.com, Foubister AJ, Bioorganic and Medicinal Chemistry Letters . 2001,第16期

机译：考虑抑制剂pK（a）衍生的新型氧化氧角鲨烯环化酶-羊毛甾醇合酶的4-哌啶子吡啶抑制剂。
3. Crystal Structures of Full-Length Lanosterol 14 alpha-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery [J] . Keniya Mikhail V, Sabherwal Manya, Wilson Rajni K., Antimicrobial agents and chemotherapy. . 2018,第11期

机译：全长Lanterol醇的晶体结构14初始真菌病原体念珠菌念珠菌和念珠菌的蛋白质蛋白酶和Candida Glabrata提供抗真菌探索的工具
4. Molecular Docking Studies Flavonoid (Quercetin, Isoquercetin, and Kaempferol) of Single Bulb Garlic (Allium sativum) to Inhibit Lanosterol Synthase as Anti-hypercholesterol Therapeutic Strategies [C] . Maghfiroh Gesty Maharani, Sri Rahayu Lestari, Betty Lukiati International Conference on Life Sciences and Technology . 2020

机译：分子对接研究单灯泡大蒜（Allium sativum）的黄酮（槲皮素，异喹啉，kaempferol），以抑制Lanterosol合酶作为抗高胆固醇治疗策略
5. NG-nitro-L-arginine-containing peptidomimetics as selective neuronal nitric oxide synthase inhibitors. Structure-based design, synthesis, and biological evaluation and approaches toward enhanced CNS activity. [D] . Seo, Jiwon. 2006

机译：含NG-硝基-L-精氨酸的拟肽作为选择性神经元一氧化氮合酶抑制剂。基于结构的设计，合成和生物学评估以及增强CNS活性的方法。
6. Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery [O] . Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, 2018

机译：突出的真菌病原体白色念珠菌和光滑念珠菌的全长羊毛甾醇14α-脱甲基酶的晶体结构为抗真菌发现提供了工具
7. Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery [O] . Mikhail V. Keniya, Manya Sabherwal, Rajni K. Wilson, 2018

机译：突出真菌病原体念珠菌念珠菌念珠菌和念珠菌的全长Lanterol14α-脱甲基酶的晶体结构为抗真菌发现提供了工具

Revised Structures of Epohelmins A and B Isolated as Lanosterol Synthase Inhibitors from a Fungal Strain FKI-0929

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