Prunustatin A,a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger

Yukiko Umeda; Shuhei Chijiwa; Kazuo Furihata; Keiko Furihata; Shohei Sakuda; Hiromichi Nagasawa; Hidenori Watanabe; Kazuo Shin-ya

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Prunustatin A,a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger

【24h】

Prunustatin A,a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger

机译：Prunustatin A，一种新型的从葡萄链霉菌分离的GRP78分子伴侣下调剂

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In the course of our screening program for regulators of a molecular chaperone GRP78 expression,we isolated a novel inhibitor of GRP78 expression,designated as prunustatin A,from Streptomyces violaceoniger 4521-SVS3.The structure of prunustatin A was determined by a series of NMR analyses to be an oxidized type of the neoantimycin family.Prunustatin A inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells accompanied by global cell death without showing cytotoxicity under normal nutrient condition.

机译：在分子伴侣蛋白GRP78表达调节剂的筛选程序中，我们从紫链霉菌4521-SVS3中分离了一种新的GRP78表达抑制剂，称为苦味素A。通过一系列NMR分析确定了苦味素A的结构。苦参素A抑制2-脱氧葡萄糖诱导的人纤维肉瘤HT1080细胞中GRP78的表达并伴有整体细胞死亡，而在正常营养条件下不表现出细胞毒性。

著录项

来源
《The Journal of Antibiotics: An International Journal》 |2005年第3期|共4页
作者
Yukiko Umeda; Shuhei Chijiwa; Kazuo Furihata; Keiko Furihata; Shohei Sakuda; Hiromichi Nagasawa; Hidenori Watanabe; Kazuo Shin-ya;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类药学;
关键词
molecular chaperone; GRP78; glucose deprivation; prunustatin;

机译：分子伴侣;GRP78;葡萄糖剥夺;苦参素;

相似文献

外文文献
中文文献
专利

1. Prunustatin A,a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger [J] . Yukiko Umeda, Shuhei Chijiwa, Kazuo Furihata, The Journal of Antibiotics: An International Journal . 2005,第3期

机译：Prunustatin A，一种新型的从葡萄链霉菌分离的GRP78分子伴侣下调剂
2. Absolute Structure of Prunustatin A, a Novel GRP78 Molecular Chaperone Down-Regulator [J] . Yukiko Umeda, Kazuo Furihata, Shohei Sakuda, Organic letters . 2007,第21期

机译：新型GRP78分子伴侣下调剂Prunustatin A的绝对结构
3. Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator [J] . Umeda Y, Furihata K, Sakuda S, Organic letters . 2007,第21期

机译：新型GRP78分子伴侣下调剂Prunustatin A的绝对结构
4. Fermentation of antimicrobial substances of Streptomyces sp. BCy isolated from seagrass Cymodocearotundata using two different media [C] . V. Damayanti, R. N. Rachma, I. Santoso, International Symposium on Current Progress in Mathematics and Sciences . 2018

机译：STREXTOMYCES SP的抗微生物物质发酵。 BCY使用两种不同的媒体从海草Cymodocearotundata隔离
5. Role of endoplasmic reticulum chaperones GRP78 and GRP94 in regulating unfolded protein response and cell survival. [D] . Wang, Miao. 2010

机译：内质网伴侣蛋白GRP78和GRP94在调节未折叠的蛋白应答和细胞存活中的作用。
6. Nucleotide sequence of the xylose isomerase gene from Streptomyces violaceoniger. [O] . D Drocourt, S Bejar, T Calmels, 1988

机译：来自紫链霉菌的木糖异构酶基因的核苷酸序列。
7. Prunustatin A, a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger [O] . Yukiko Umeda, Shuhei Chijiwa, Kazuo Furihata, 2005

机译：prunustatin a，一种新的GRP78分子伴侣抑制因子与Streptomyces violachiger分离

Prunustatin A,a Novel GRP78 Molecular Chaperone Down-regulator Isolated from Streptomyces violaceoniger

摘要

著录项

相似文献

相关主题

期刊订阅