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首页> 外文期刊>The Journal of cardiovascular nursing >beta2-Adrenergic Receptor Genotype Predicts Survival
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beta2-Adrenergic Receptor Genotype Predicts Survival

机译:beta2-肾上腺素能受体基因型预测存活率

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摘要

Our previously published data indicate that patients prescribed p-b!ocker (BB) therapy after an acute coronary syndrome have differential survival associated with their ADRB2 genotypes. These sequence variants can risk-stratify patients receiving BB therapy and may predict BB efficacy post-acute coronary syndrome. This report summarizes our findings and describes their implications for clinical care as well as future research directions. In the near term, we and other researchers will focus on validating our findings in an independent population. In the longer term, reassessment of the benefits of BB therapy within genotype groups should be pursued, and extension of these findings into other disease states where BB therapy or adrenergic stimulation is important (eg, heart failure) should be considered. Much of this work is already underway and is likely to influence the future standard of cardiovascular care.
机译:我们先前发表的数据表明,急性冠脉综合征后接受p-bocker(BB)治疗的患者具有与其ADRB2基因型相关的不同生存率。这些序列变异可对接受BB治疗的患者进行风险分层,并可预测急性冠状动脉综合征后的BB疗效。本报告总结了我们的发现,并描述了它们对临床护理的意义以及未来的研究方向。在短期内,我们和其他研究人员将专注于在独立人群中验证我们的发现。从长远来看,应该对基因型组中BB治疗的益处进行重新评估,并将这些发现扩展到BB治疗或肾上腺素能刺激很重要的其他疾病状态(例如心力衰竭)。这项工作大部分已经在进行中,并且可能会影响心血管保健的未来标准。

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