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首页> 外文期刊>Chemistry of heterocyclic compounds >Psychotropic Preparations Sydnophen and Sydnocarb as Donors of Nitrogen Monoxide
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Psychotropic Preparations Sydnophen and Sydnocarb as Donors of Nitrogen Monoxide

机译:精神制剂赛诺芬和昔诺威作为一氧化氮的捐助者

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摘要

The metabolic chain of the antihypertensive drug Molsydomin, which belongs to the group of sydnonimine derivatives, was modelled in vitro with the psychotropic drugs Sydnophen and Sydnocarb, which are also derivatives of sydnonimine. Like Molsydomin, Sydnophen and Sydnocarb are hydrolyzed to N-nitroso compounds which liberate nitrogen monoxide, NO, on subsequent oxidation which may be related to the pharmacological effects of these drugs.
机译:降血压药莫尔斯多明的代谢链属于sydnonimine衍生物,是利用精神药物Sydnophen和Sydnocarb(也是sydnonimine的衍生物)在体外模拟的。像Molsydomin一样,Sydnophen和Sydnocarb水解为N-亚硝基化合物,在随后的氧化反应中释放出一氧化氮NO,这可能与这些药物的药理作用有关。

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