• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Hypotension and bradycardia in a healthy volunteer following a single 5 mg dose of olanzapine.
【24h】

Hypotension and bradycardia in a healthy volunteer following a single 5 mg dose of olanzapine.

机译：服用5毫克奥氮平后，健康志愿者的低血压和心动过缓。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Olanzapine is an atypical antipsychotic medication indicated for the treatment of schizophrenia and other manifestations of psychotic illness. Common side effects include somnolence, constipation, weight gain, and postural hypotension. The authors report a case of hypotension accompanied by bradycardia in a normal, healthy volunteer participating in an olanzapine pharmacokinetic study following a single 5 mg dose. A venous catheter allowed for serial blood sampling of olanzapine concentrations before, during, and after the adverse event. The subject experienced a rapid absorption of the drug and higher than anticipated maximum plasma concentrations. This case suggests that atypical antipsychotics, although generally better tolerated than conventional agents, may still result in untoward reactions that may be partially due to individual differences in drug absorption and metabolism.
机译：奥氮平是一种非典型的抗精神病药物，用于治疗精神分裂症和其他精神疾病。常见的副作用包括嗜睡，便秘，体重增加和体位性低血压。作者报告了在参加一次奥氮平药代动力学研究的正常，健康志愿者中，一次服用5毫克低血压并伴有心动过缓。静脉导管允许在不良事件发生之前，之中和之后对奥氮平浓度进行连续血液采样。受试者经历了药物的快速吸收并且高于预期的最大血浆浓度。这种情况表明，非典型抗精神病药虽然通常比常规药物耐受性更好，但仍可能导致不良反应，这可能部分是由于药物吸收和代谢的个体差异所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号