• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Electrocardiographic effects of rivastigmine.
【24h】

Electrocardiographic effects of rivastigmine.

机译：卡巴拉汀的心电图作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The electrocardiographic (ECG) effects of rivastigmine treatment were assessed in mild to moderately severe Alzheimer's disease (AD) by analysis of four 26-week, double-blind, multicenter, placebo-controlled, phase III clinical trials. Of an initial 2791 patients, 77% completed treatment. Seventy-one percent required at least one concomitant medication for conditions other than AD, with 34% requiring cardiovascular medications. Safety assessments included ECGs, adverse events, vital signs, and clinical laboratory parameters. Pooled 12-lead ECG data were analyzed by an independent cardiologist blinded to treatment group and clinical information. Heart rate, PR, QRS, and QTc intervals did not differ significantly between treatment and placebo groups. Percentage change from baseline for PR, QRS, and QTc intervals was also no different. In conclusion, rivastigmine appears not to produce adverse effects on cardiac function assessed by ECG.
机译：通过分析四项为期26周，双盲，多中心，安慰剂对照的III期临床试验，评估了轻，中度重度阿尔茨海默氏病（AD）对卡巴拉汀治疗的心电图（ECG）效果。在最初的2791名患者中，有77％完成了治疗。 71％的人在AD以外的疾病中至少需要一种同时用药，而34％的人需要心血管药物。安全评估包括心电图，不良事件，生命体征和临床实验室参数。由不了解治疗组和临床信息的独立心脏病专家分析了汇总的12导联心电图数据。治疗组和安慰剂组之间的心率，PR，QRS和QTc间隔无明显差异。 PR，QRS和QTc间隔相对于基线的百分比变化也没有差异。总之，卡巴拉汀似乎对心电图评估的心脏功能没有产生不良影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号