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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Endocrine effects of marijuana.
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Endocrine effects of marijuana.

机译：大麻的内分泌作用。

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摘要

In the 35 years since the active compound of marijuana, delta9-tetrahydrocannabinol, was isolated, the psychological and physiological impact of marijuana use has been actively investigated. Animal models have demonstrated that cannabinoid administration acutely alters multiple hormonal systems, including the suppression of the gonadal steroids, growth hormone, prolactin, and thyroid hormone and the activation of the hypothalamic-pituitary-adrenal axis. These effects are mediated by binding to the endogenous cannabinoid receptor in or near the hypothalamus. Despite these findings in animals, the effects in humans have been inconsistent, and discrepancies are likely due in part to the development of tolerance. The long-term consequences of marijuana use in humans on endocrine systems remain unclear.
机译：自从大麻的活性化合物delta9-tetrahydrocannabinol被分离以来的35年中，人们一直在积极研究使用大麻的心理和生理影响。动物模型表明，大麻素的给药会急剧改变多种激素系统，包括抑制性腺类固醇，生长激素，催乳激素和甲状腺激素以及激活下丘脑-垂体-肾上腺轴。这些作用是通过与下丘脑内或附近的内源性大麻素受体结合而介导的。尽管在动物中发现了这些发现，但在人类中的作用却不一致，差异可能部分归因于耐受性的发展。尚不清楚人类使用大麻对内分泌系统的长期影响。

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