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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Effect of phosphate binders on supplemental iron absorption in healthy subjects.
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Effect of phosphate binders on supplemental iron absorption in healthy subjects.

机译：磷酸盐粘合剂对健康受试者补充铁的吸收的影响。

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摘要

A single-dose, prospective, randomized, four-treatment, four-period crossover study was conducted to determine the acute effect of therapeutically equivalent doses of three commonly used phosphate binders on oral iron absorption. Twenty-three healthy subjects received 65 mg of elemental iron alone and with each phosphate binder (calcium carbonate 3000 mg, calcium acetate 2668 mg, or sevelamer HCl 2821 mg). Area under the change in plasma iron concentration-time curve over 6 hours postdosing was measured. ANOVA was used to assess the statistical significance of differences in iron absorption among the treatments. The relative bioavailability of iron administered with each phosphate binder compared to iron administered alone was estimated. The relative iron bioavailabilities (95% confidence intervals) for the calcium carbonate, calcium acetate, and sevelamer HCI treatments were 0.81 (0.70, 0.94), 0.73 (0.63, 0.85), and 0.90 (0.78, 1.05), respectively. Thus, single doses of both calcium-based phosphate binders significantly reduced single-dose iron absorption, while sevelamer HCl did not.
机译：进行了单剂量，前瞻性，随机，四治疗，四时期交叉研究，以确定治疗等效剂量的三种常用磷酸盐结合剂对口服铁吸收的急性作用。 23名健康受试者单独接受65 mg元素铁，并与每种磷酸盐结合剂（碳酸钙3000 mg，乙酸钙2668 mg或司维拉姆HCl 2821 mg）一起接受治疗。在给药后6小时内测量血浆铁浓度-时间曲线变化下的面积。方差分析用于评估各处理之间铁吸收差异的统计显着性。估计与单独施用铁相比，与每种磷酸盐结合剂一起施用的铁的相对生物利用度。碳酸钙，乙酸钙和司维拉姆盐酸盐处理的相对铁生物利用度（95％置信区间）分别为0.81（0.70，0.94），0.73（0.63，0.85）和0.90（0.78，1.05）。因此，两种钙基磷酸酯粘合剂的单剂量均可显着降低单剂量铁的吸收，而司维拉姆HCl则不能。

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