• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Analgesic dose-response relationship of ibuprofen 50, 100, 200, and 400 mg after surgical removal of third molars: a single-dose, randomized, placebo-controlled, and double-blind study of 304 patients.
【24h】

Analgesic dose-response relationship of ibuprofen 50, 100, 200, and 400 mg after surgical removal of third molars: a single-dose, randomized, placebo-controlled, and double-blind study of 304 patients.

机译：手术摘除第三磨牙后布洛芬50、100、200和400 mg的镇痛剂量反应关系：304例患者的单剂量，随机，安慰剂对照和双盲研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this single-dose, randomized, placebo-controlled, and double-blind study was to evaluate the analgesic dose-response relationship of 50-mg, 100-mg, 200-mg, and 400-mg doses of ibuprofen after third molar surgery. Patients were instructed to take a single dose of either placebo or 50 mg, 100 mg, 200 mg, or 400 mg of ibuprofen when the postoperative pain was moderate to severe. Acetaminophen 500 mg was used as a rescue medication. Pain intensity, pain relief, and any possible adverse events were recorded on self-administered questionnaires hourly for 6 hours after intake of study medication. If rescue medication was taken, the time of intake was registered. A total of 304 patients entered the study, and 258 complied with the protocol. A positive analgesic dose-response relationship of 50-mg, 100-mg, 200-mg, and 400-mg doses of ibuprofen was observed when evaluated by pain intensity difference, sum of pain intensity difference, pain relief, total pain relief, and survival distribution of patients not taking rescue medication. Although significant pain relief was seen after a dose of 50 mg ibuprofen, ibuprofen 400 mg provided maximum pain relief and the longest duration of analgesic effect. Mild transient adverse events were reported by 6.8% of the patients. However, there was no significant difference in frequency between the placebo and 50 mg, 100 mg, 200 mg, and 400 mg ibuprofen dose groups.
机译：这项单剂量，随机，安慰剂对照和双盲研究的目的是评估第三次布洛芬后50毫克，100毫克，200毫克和400毫克剂量的镇痛剂量反应关系。磨牙手术。当术后疼痛为中度至重度时，指示患者单次服用安慰剂或50 mg，100 mg，200 mg或400 mg布洛芬。对乙酰氨基酚500毫克用作急救药物。服用研究药物后6小时，每小时一次在自我管理的问卷中记录疼痛强度，疼痛缓解和任何可能的不良事件。如果服用了急救药物，则记录摄入时间。共有304位患者进入了研究，其中258位患者符合该方案。当通过疼痛强度差异，疼痛强度差异总和，疼痛缓解，总疼痛缓解和疼痛程度进行评估时，观察到50 mg，100 mg，200 mg和400 mg剂量的布洛芬具有积极的镇痛剂量反应关系。不服用急救药物的患者的生存分布。尽管在服用50毫克布洛芬后可明显缓解疼痛，但400毫克布洛芬可最大程度地缓解疼痛，并具有最长的止痛效果。 6.8％的患者报告了轻度的短暂不良事件。但是，安慰剂与50 mg，100 mg，200 mg和400 mg布洛芬剂量组之间的频率无明显差异。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号