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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Fenoldopam: a new dopamine agonist for the treatment of hypertensive urgencies and emergencies.
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Fenoldopam: a new dopamine agonist for the treatment of hypertensive urgencies and emergencies.

机译：非诺多m：一种新的多巴胺激动剂，用于治疗高血压急症和紧急情况。

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摘要

Fenoldopam is a selective dopamine agonist that is being considered for the parenteral treatment of systemic hypertension. In both an oral and parenteral form, the drug causes peripheral vasodilation by stimulating dopamine-1 adrenergic receptors. Its pharmaco-dynamics are reviewed in this article, along with the clinical experiences in patients with hypertensive urgencies and emergencies. Intravenous fenoldopam may provide advantages over sodium nitroprusside because it can induce both a diuresis and natriuresis, is not light sensitive, and is not associated with cyanide toxicity. There is no evidence for rebound hypertension after discontinuation of fenoldopam influsion.
机译：非诺多m是一种选择性的多巴胺激动剂，正在考虑用于肠胃外治疗系统性高血压。在口服和非肠道形式下，该药物均通过刺激多巴胺-1肾上腺素能受体引起周围血管舒张。本文对它的药效动力学以及高血压急症和紧急情况的临床经验进行了综述。静脉注射非诺多m可能比硝普钠更具优势，因为它既可以诱导利尿和利尿作用，对光也不敏感，并且与氰化物毒性无关。没有证据表明停用非诺多m后可出现反弹性高血压。

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