• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Pharmacokinetics and pharmacodynamics of scopolamine after subcutaneous administration.
【24h】

Pharmacokinetics and pharmacodynamics of scopolamine after subcutaneous administration.

机译：皮下给药后东pol碱的药代动力学和药效学。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of subcutaneously administered scopolamine on quantitative electroencephalogram (qEEG) and cognitive performance were evaluated and correlated with pharmacokinetic parameters in a randomized, double-blind placebo-controlled crossover study of 10 healthy male volunteers. Changes in qEEG and cognition were determined for 8 hours after drug administration. Scopolamine produced dose- and time-dependent impairments of attention and memory and a time-dependent increase in delta power (1.25-4.50 Hz) and a decrease in fast alpha power (9.75-12.50 Hz) on qEEG compared with placebo. Maximum serum concentrations of scopolamine occurred 10 to 30 minutes after drug administration. Mean peak serum concentrations (free base) were 3.27, 8.99, and 18.81 ng/mL after administration of 0.4, 0.6 mg, and 0.8 mg scopolamine, respectively. Elimination half-life was approximately 220 minutes. The findings indicate temporary changes in qEEG and psychometric tests, and support the possible use of such a testing model for impaired cognitive functions such as age-related memory disturbances.
机译：在一项随机，双盲，安慰剂对照的交叉研究中，对10名健康男性志愿者进行了皮下注射东pol碱对定量脑电图（qEEG）和认知能力的影响，并将其与药代动力学参数相关联。在给药后8小时确定qEEG和认知的变化。与安慰剂相比，东pol碱在qEEG上引起注意力和记忆的剂量和时间依赖性损害，δ功率（1.25-4.50 Hz）随时间变化而增加，快速α功率（9.75-12.50 Hz）随时间下降。东drug碱的最大血清浓度在给药后10至30分钟出现。分别服用0.4、0.6 mg和0.8 mg东pol碱后，平均峰值血清浓度（游离碱）分别为3.27、8.99和18.81 ng / mL。消除半衰期约为220分钟。这些发现表明qEEG和心理测验的暂时变化，并支持这种测验模型用于认知功能受损（例如与年龄有关的记忆障碍）的可能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号