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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Lack of interaction between tramadol and coumarins.
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Lack of interaction between tramadol and coumarins.

机译：曲马多和香豆素之间缺乏相互作用。

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摘要

The objective of this study was to investigate whether the central analgesic tramadol influences the effects of the coumarin anticoagulant phenprocoumon during multiple-dose administration. Nineteen patients receiving long-term anticoagulant therapy who had been in a stable hypothrombinemic state for at least 3 months completed a double-blind, placebo-controlled, crossover study. Tramadol was administered in the usual therapeutic dose of 50 mg three times daily. The average daily phenprocoumon dose was identical for individual patients in both treatment periods. The equivalence ratio (tramadol/placebo) of the international normalized ratio (INR) values was 0.99 (90% confidence interval 0.89-1.10), thus fulfilling predetermined bioequivalence criteria (0.70-1.43). Therefore, tramadol does not affect INR in patients being treated with phenprocoumon. These data suggest a lack of interaction between tramadol and coumarin anticoagulants.
机译：这项研究的目的是调查在多剂量给药期间中枢镇痛曲马多是否会影响香豆素抗凝剂苯丙香豆素的作用。长期处于稳定的血栓栓塞性状态至少3个月的接受长期抗凝治疗的19名患者完成了一项双盲，安慰剂对照，交叉研究。曲马多的常规治疗剂量为50毫克，每天3次。在两个治疗期中，个别患者的平均苯丙香酚平均日剂量相同。国际标准化比率（INR）值的当量比（曲马多/安慰剂）为0.99（90％置信区间0.89-1.10），从而满足预定的生物等效性标准（0.70-1.43）。因此，曲马多不会影响苯酚普鲁蒙治疗患者的INR。这些数据表明曲马多和香豆素抗凝剂之间缺乏相互作用。

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