A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.

Barditch-Crovo P; Noe D; Skowron G; Lederman M; Kalayjian RC; Borum P; Buier R; Rowe WB; Goldberg D; Lietman P

首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.

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A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.

机译：对感染人免疫缺陷病毒的无症状患者口服L-2-氧噻唑烷-4-羧酸进行I / II期I / II期评估。

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A randomized double-blind, placebo-controlled study was conducted in 37 asymptomatic HIV-infected individuals (mean CD4 count 707 cells/mm3) to characterize the safety, pharmacokinetics, and effect on blood thiols of three dosage levels of a cysteine prodrug, L-2-oxothiazolidine-4-carboxylic acid (OTC; Procysteine; Clintec Technologies, Deerfield, IL). Single-dose administration of OTC resulted in measurable plasma levels at all dosages, with a mean peak plasma concentration of 734 +/- 234 nmol/mL at the highest dosage studied. After 4 weeks of administration three times daily, a statistically significant increase was seen in whole blood glutathione in the 1,500 mg and 3,000 mg dose groups compared with the placebo group. A significant increase in whole blood cysteine and peripheral blood mononuclear cell (PBMC) glutathione was not seen during the study period.

机译：在37个无症状HIV感染者中进行了一项随机双盲，安慰剂对照研究（平均CD4计数707细胞/ mm3），以表征三种剂量水平的半胱氨酸前药L的安全性，药代动力学和对血硫醇的影响-2-氧噻唑烷-4-羧酸（OTC;脯氨酸; Clintec Technologies，Deerfield，IL）。在所有剂量下，单剂量OTC均可产生可测量的血浆水平，在研究的最高剂量下，平均峰值血浆浓度为734 +/- 234 nmol / mL。每天3次给药4周后，与安慰剂组相比，在1500 mg和3,000 mg剂量组中，全血谷胱甘肽有统计学意义的增加。在研究期间未见全血半胱氨酸和外周血单核细胞（PBMC）谷胱甘肽的显着增加。

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来源
《The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology》 |1998年第4期|共7页
作者
Barditch-Crovo P; Noe D; Skowron G; Lederman M; Kalayjian RC; Borum P; Buier R; Rowe WB; Goldberg D; Lietman P;
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正文语种 eng
中图分类药理学;
关键词
Anti-HIV Agents; HIV Infections; Prodrugs; Thiazoles; 2-oxothiazolidine-4-carboxylic acid; 抗HIV药; HIV感染; 药物前体; 噻唑类;

机译：Anti-HIV Agents;HIV Infections;Prodrugs;Thiazoles;2-oxothiazolidine-4-carboxylic acid;抗HIV药;HIV感染;药物前体;噻唑类;

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1. A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus. [J] . Barditch-Crovo P, Noe D, Skowron G, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 1998,第4期

机译：对感染人免疫缺陷病毒的无症状患者口服L-2-氧噻唑烷-4-羧酸进行I / II期I / II期评估。
2. Penicillium marneffei infection presenting as oral ulcerations in a patient infected with human immunodeficiency virus. [J] . Tong AC, Wong- M, Smith NJ Journal of Oral and Maxillofacial Surgery . 2001,第8期

机译：在感染了人类免疫缺陷病毒的患者中，马尔尼菲青霉菌感染表现为口腔溃疡。
3. Characterization of genetically distinct subgroup of Candida albicans strains isolated from oral cavities of patients infected with human immunodeficiency virus. [J] . M McCullough, B Ross, P Reade Journal of Clinical Microbiology . 1995,第3期

机译：从人类免疫缺陷病毒感染患者的口腔中分离出白色念珠菌菌株的遗传上不同的亚组。
4. Fuzzy Decision of Drug Dosage for Type-1 Human Immunodeficiency Virus Infected Patients [C] . Na Fu, Wenjie Zhang, Xiangpeng Xie IEEE International Conference on Cloud Computing and Intelligent Systems . 2018

机译：1型人类免疫缺陷病毒感染患者用药剂量的模糊决策
5. Human papillomavirus: Deoxyribonucleic acid detection, association with papanicolaou smears, and co-infection with human immunodeficiency virus. [D] . Slavinsky, Joseph, III. 2000

机译：人乳头瘤病毒：脱氧核糖核酸检测，与木瓜涂片相关，并与人免疫缺陷病毒共同感染。
6. Comparison of oral fluconazole and clotrimazole troches as treatment for oral candidiasis in patients infected with human immunodeficiency virus. [O] . S L Koletar, J A Russell, R J Fass, 1990

机译：口服氟康唑和克霉唑锭剂治疗感染人免疫缺陷病毒患者的口腔念珠菌病的比较。
7. Comparison of oral fluconazole and clotrimazole troches as treatment for oral candidiasis in patients infected with human immunodeficiency virus. [O] . Koletar, S L, Russell, J A, Fass, R J, 1990

机译：口服氟康唑和克霉唑锭剂治疗感染人免疫缺陷病毒患者的口腔念珠菌病的比较。
8. Morbidity and Mortality Weekly Report, January 31, 2003, Volume 52, Number RR-2. Guidelines for Performing Single-Platform Absolute CD4(+) T-Cell Determinations with CD45 Gating for Persons Infected with Human Immunodeficiency Virus. Guidelines for Using [R] . Hewitt, S. M. 2003

机译：针对人类免疫缺陷病毒感染者使用CD45门控进行单平台绝对CD4（+）T细胞测定的指南。使用指南

A phase I/II evaluation of oral L-2-oxothiazolidine-4-carboxylic acid in asymptomatic patients infected with human immunodeficiency virus.

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