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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Gender differences in adverse drug reactions.
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Gender differences in adverse drug reactions.

机译：药物不良反应中的性别差异。

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摘要

The objective of this study is to identify gender-related differences in the types of symptoms and drugs reported to cause an adverse drug reaction. Patient data from the Sunnybrook Health Science Centre ADR Clinic for the period from April 1986 to May 1996 were reviewed. Of the 2,367 patients assessed, 74.1% were female. The mean age of the patients was 43 +/- 17 years. Drug classes most frequently reported to elicit an adverse event were general antiinfectives (60.4%), nervous system agents (21.5%), and musculoskeletal agents (3.7%). Skin-related reactions accounted for 49.0% of all reported adverse drug reactions. More than one agent was reported to be responsible for the adverse drug reaction(s) in 50% of the female patients, versus 33.1% of all male patients. Of the female patients, 47.6% were referred for skin or oral challenge testing, versus 41.6% of the male patients. Of the female patients, 6.2% tested positive to the agent compared with 6.1% of all male patients. These results support previous findings that female gender is a risk factor for the development of adverse drug reactions. Further work is required to elucidate the mechanisms explaining the differences observed between male and female patients.
机译：这项研究的目的是确定与性别有关的症状和所报告的引起药物不良反应的药物类型的差异。回顾了1986年4月至1996年5月期间来自Sunnybrook健康科学中心ADR诊所的患者数据。在评估的2367名患者中，女性占74.1％。患者的平均年龄为43 +/- 17岁。最常报告的引发不良事件的药物类别是一般抗感染药（60.4％），神经系统药（21.5％）和肌肉骨骼药（3.7％）。皮肤相关反应占所有报告的药物不良反应的49.0％。据报道，在50％的女性患者中，有一种以上的药物对药物不良反应负责，而在所有男性患者中，药物的不良反应为33.1％。在女性患者中，有47.6％的患者接受皮肤或口腔挑战测试，而男性患者为41.6％。在女性患者中，有6.2％对该药物测试呈阳性，而在所有男性患者中为6.1％。这些结果支持以前的发现，即女性是药物不良反应发生的危险因素。需要进一步的工作来阐明解释男性和女性患者之间观察到的差异的机制。

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