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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >A dose-ranging study of gentamicin pharmacokinetics: implications for extended interval aminoglycoside therapy.
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A dose-ranging study of gentamicin pharmacokinetics: implications for extended interval aminoglycoside therapy.

机译：庆大霉素药代动力学的剂量范围研究：对延长间隔氨基糖苷治疗的意义。

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摘要

Prolonged distribution time has been noted for high-dose (7 mg/kg) gentamicin. Higher doses are used for extended-interval aminoglycoside therapy (EIA). The authors investigated whether the increase in distribution time was proportional to the dose of gentamicin. Twelve healthy volunteers were given low (LD, 2 mg/kg), medium (MD, 4.5 mg/kg), and high (HD, 7 mg/kg) doses of gentamicin in a randomized, crossover fashion. Gentamicin was infused over 30 minutes, with 15 concentrations obtained over 8 hours after each dose. Data were fit to a two-compartment pharmacokinetic model. Distribution half-life for HD (31.1 +/- 5.7 min) differed significantly (p < 0.05) from LD (22.4 +/- 6.1 min) and MD (23.8 +/- 5.1 min) with no significant difference being seen between LD and MD. This study verifies that when using EIA dosing with HD gentamicin, sampling within 90 minutes after the beginning of the infusion provides information that leads to overestimation of peak serum concentration/minimum inhibitory concentration and inaccurate calculation of pharmacokinetic parameters.
机译：大剂量庆大霉素（7 mg / kg）的分发时间延长。高剂量用于延长间隔的氨基糖苷治疗（EIA）。作者研究了分配时间的增加是否与庆大霉素的剂量成正比。 12名健康志愿者以随机，交叉的方式分别服用低剂量（LD，2 mg / kg），中剂量（MD，4.5 mg / kg）和高剂量（HD，7 mg / kg）庆大霉素。庆大霉素在30分钟内被注入，每次给药后8小时内获得15种浓度。数据符合两室药代动力学模型。 HD（31.1 +/- 5.7分钟）的分布半衰期与LD（22.4 +/- 6.1分钟）和MD（23.8 +/- 5.1分钟）有显着差异（p <0.05），而LD和医师这项研究证实，当将EIA剂量与HD庆大霉素一起使用时，在输注开始后90分钟内取样可提供导致峰值血清浓度/最小抑菌浓度高估和药代动力学参数计算不准确的信息。

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