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首页> 外文期刊>The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology >Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches.
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Pharmacokinetics of norelgestromin and ethinyl estradiol from two consecutive contraceptive patches.

机译：连续两个避孕贴片中的诺列非斯特罗汀和炔雌醇的药代动力学。

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摘要

The primary objective of this open-label study was to determine the pharmacokinetics of norelgestromin (NGMN) and ethinyl estradiol (EE)following two consecutive applications of a contraceptive patch (ORTHO EVRA/EVRA). Twelve healthy women wore the first patch on their abdomen for 7 days and, after removal at 168 hours (day 7), wore a second patch for 10 days (i.e., 3 days beyond the intended 7-day wear period). Blood samples were collected before and at various times up to 456 hours (day 19) after application of the first patch for analysis of NGMN and EE. Mean serum concentrations of NGMN and EE remained within the reference ranges, 0.6 to 1.2 ng/ml and 25 to 75 pg/ml, respectively, during the entire 7-day wear period after application of the first patch and for 10 days after application of the second patch; reference ranges are based on studies with ORTHO-CYCLEN/ Cilest. No patch detached spontaneously. No subject discontinued or experienced a serious adverse event.
机译：这项开放标签研究的主要目的是在连续两次避孕药贴剂（ORTHO EVRA / EVRA）之后，测定去甲炔诺孕酮（NGMN）和炔雌醇（EE）的药代动力学。十二名健康女性在腹部上第一次贴了7天，在168小时（第7天）摘除后，又在第二天贴了10天（即，超出预期的7天佩戴时间3天）。在使用第一个贴片进行NGMN和EE分析之前和之后的456小时（第19天）之前和之后的不同时间采集血样。在施用第一个贴剂后的整个7天穿着期间和施用PBX后的10天内，NGMN和EE的平均血清浓度分别保持在参考范围内，分别为0.6至1.2 ng / ml和25至75 pg / ml。第二个补丁;参考范围基于对ORTHO-CYCLEN / Cilest的研究。没有补丁自发脱落。没有受试者中断或经历严重的不良事件。

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